Multimodal regional nerve blocks to improve recovery after off-pump CABG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study explores a multimodal regional anesthesia approach for adults undergoing elective off-pump CABG via sternotomy. It compares a combination of blocks with a placebo, aiming to reduce opioid needs and improve recovery markers. The design targets pain from sternotomy, graft harvest, chest wall retraction, and drain sites, with inclusion restricted to ASA III–IV patients and excludes those with contraindications to regional anesthesia or chronic opioid use. Outcomes likely include pain scores, opioid consumption, extubation time, and mobility measures. The study is conducted at Ain Shams University Hospitals in Cairo, with Ain Shams University as the lead sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* o Scheduled for elective off-pump coronary artery bypass graft (OPCAB) surgery via median sternotomy

  * American Society of Anesthesiologists (ASA) physical status III - IV
  * Ability to provide informed consent

Exclusion Criteria:

* o Emergency or redo cardiac surgery

  * On-pump CABG or concomitant valve or aortic procedures
  * Known allergy to local anesthetics or study drugs
  * Coagulopathy or ongoing anticoagulant therapy contraindicating regional block
  * Preoperative chronic opioid use or opioid dependency
  * Neurologic or psychiatric conditions interfering with pain assessment
  * Infection at the block injection site
  * Severe hepatic or renal impairment
  * Body mass index (BMI) \> 40 kg/m²
  * Inability to understand or cooperate with pain scoring or postoperative care.

Where it's running

• Ain shams university hospitals
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Abdelrahman H Ashour
• Email: AbdelrahmanAshour@med.asu.edu.eg
• Phone: +2-1010184467

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.