CMR markers that predict outcomes after ischemic heart disease or heart attack
Official title: Prognostic Value of Multiparametric Cardiovascular Magnetic Resonance in Patients With Ischemic Heart Disease: A Multicenter Retrospective Cohort Study
Run by Chinese Academy of Medical Sciences, Fuwai Hospital · NCT07351825 · Data updated 2026-11-12
This study will test whether specific heart MRI (CMR) features can help predict long-term risk in adults with ischemic heart disease or a prior myocardial infarction.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Chinese Academy of Medical Sciences, Fuwai Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | January 2009 |
| Main results expected | December 2035 |
| Study ends | December 2035 |
| Registry record updated | January 20, 2026 |
| Trial ID | NCT07351825 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with ischemic heart disease or prior/recent myocardial infarction who had clinically indicated, analyzable CMR scans and available follow-up data are the ideal candidates for inclusion.
✕Probably not a fit
Patients without usable CMR images, with non-ischemic cardiac conditions, major comorbid illnesses that limit life expectancy, or missing outcome data are unlikely to benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter retrospective study uses existing clinical and CMR imaging records from patients with ischemic heart disease who underwent clinically indicated CMR. Researchers will analyze multiparametric CMR markers — including late gadolinium enhancement, infarct size, microvascular obstruction, left ventricular and left atrial strain, and native T1/T2 mapping — using standardized post-processing. Baseline demographics, cardiovascular risk factors, treatments, and long-term clinical outcomes will be extracted from medical records. The primary outcome is major adverse cardiovascular and cerebrovascular events (MACCE), with cardiovascular death as a secondary endpoint.
Why it matters
Potential benefit: If successful, the findings could help clinicians better identify which IHD patients are at higher long-term risk and tailor follow-up and treatment.
How similar studies have gone: Prior CMR studies have linked LGE, infarct size, microvascular obstruction, and strain to outcomes after myocardial infarction, but large multicenter multiparametric and radiomics-driven prognostic approaches remain relatively new.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults (≥18 years of age). 2. Patients with ischemic heart disease, including prior or recent myocardial infarction, who underwent clinically indicated cardiac magnetic resonance (CMR) imaging. 3. Availability of analyzable CMR images, including but not limited to cine imaging, late gadolinium enhancement (LGE), and parametric mapping sequences (T1 and/or T2 mapping), as applicable. 4. Availability of baseline clinical data and longitudinal follow-up information. Exclusion Criteria: 1. Poor image quality or incomplete CMR data precluding quantitative analysis. 2. Presence of other severe comorbid conditions expected to significantly affect survival or clinical outcomes. 3. Missing key clinical outcome data during follow-up.
Where it's running
-
Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Zhaoxin Tian
- Email: tianzx826@163.com
- Phone: +86 18309820435
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.