CMR markers that predict outcomes after ischemic heart disease or heart attack
Prognostic Value of Multiparametric Cardiovascular Magnetic Resonance in Patients With Ischemic Heart Disease: A Multicenter Retrospective Cohort Study
This study will test whether specific heart MRI (CMR) features can help predict long-term risk in adults with ischemic heart disease or a prior myocardial infarction.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Sex | All |
| Sponsor | Chinese Academy of Medical Sciences, Fuwai Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT07351825 on ClinicalTrials.gov |
What this trial studies
This multicenter retrospective study uses existing clinical and CMR imaging records from patients with ischemic heart disease who underwent clinically indicated CMR. Researchers will analyze multiparametric CMR markers — including late gadolinium enhancement, infarct size, microvascular obstruction, left ventricular and left atrial strain, and native T1/T2 mapping — using standardized post-processing. Baseline demographics, cardiovascular risk factors, treatments, and long-term clinical outcomes will be extracted from medical records. The primary outcome is major adverse cardiovascular and cerebrovascular events (MACCE), with cardiovascular death as a secondary endpoint.
Who should consider this trial
Good fit: Adults (≥18) with ischemic heart disease or prior/recent myocardial infarction who had clinically indicated, analyzable CMR scans and available follow-up data are the ideal candidates for inclusion.
Not a fit: Patients without usable CMR images, with non-ischemic cardiac conditions, major comorbid illnesses that limit life expectancy, or missing outcome data are unlikely to benefit from this analysis.
Why it matters
Potential benefit: If successful, the findings could help clinicians better identify which IHD patients are at higher long-term risk and tailor follow-up and treatment.
How similar studies have performed: Prior CMR studies have linked LGE, infarct size, microvascular obstruction, and strain to outcomes after myocardial infarction, but large multicenter multiparametric and radiomics-driven prognostic approaches remain relatively new.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults (≥18 years of age). 2. Patients with ischemic heart disease, including prior or recent myocardial infarction, who underwent clinically indicated cardiac magnetic resonance (CMR) imaging. 3. Availability of analyzable CMR images, including but not limited to cine imaging, late gadolinium enhancement (LGE), and parametric mapping sequences (T1 and/or T2 mapping), as applicable. 4. Availability of baseline clinical data and longitudinal follow-up information. Exclusion Criteria: 1. Poor image quality or incomplete CMR data precluding quantitative analysis. 2. Presence of other severe comorbid conditions expected to significantly affect survival or clinical outcomes. 3. Missing key clinical outcome data during follow-up.
Where this trial is running
Beijing, Beijing Municipality
- Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Zhaoxin Tian
- Email: tianzx826@163.com
- Phone: +86 18309820435
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.