Loxoprofen Sodium Patch to Help Postoperative Pain After Laparoscopic Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, randomized trial investigates whether a Loxoprofen Sodium Patch used on the incision site can lessen postoperative pain in adults undergoing elective laparoscopic cholecystectomy, appendectomy, or hernia repair. Participants are adults 18-64 with ASA I-III and are randomized to receive the patch on the incision or on the opposite side, with the aim of reducing analgesic needs and side effects while improving satisfaction. The study focuses on local incision analgesia and its potential to minimize systemic analgesic requirements after surgery. Outcomes include pain levels, analgesic consumption, side effects, and patient satisfaction. The trial is conducted at Beijing Tiantan Hospital with a single lead sponsor and no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;
2. Ages 18 to 64 years old
3. American Society of Anesthesiologists (ASA) physical status of I-III
4. Patients must be able to understand the nature and potential personal consequences of the clinical trial and cooperate with follow-up investigations
5. signing of the informed consent form.

Exclusion Criteria:

1. History of chronic pain syndrome of any cause and mental illness
2. Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery.
3. History of hypertension (Grade 3, extremely high risk)
4. Pregnancy or breastfeeding.
5. Extreme body mass index (BMI) (\< 15 or \> 35).
6. Participation in another interventional trial that interferes with the intervention or outcome of this trial.
7. Digestive system diseases (such as peptic ulcers, gastric bleeding).
8. Patients with coronary artery disease.
9. Patients with renal impairment (serum creatinine \> 176 µmol/L) and abnormal liver function(alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN).
10. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran.
11. Patients with a history of allergy to anyone of the study drugs.

Where it's running

• Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Recruiting
• Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Not yet recruiting

Study contacts

• Study coordinator: Fang Luo
• Email: 13611326978@163.com
• Phone: +86 13611326978

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pre-incisional ropivacaine plus triamcinolone for pain after laparoscopic surgery

  This trial tests whether injecting ropivacaine with or without triamcinolone before incision can reduce postoperative pain in adults undergoing common laparoscopic procedures like gallbladder removal, appendix removal, or hernia repair.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07591233

• Effect of extraction site and local anesthesia on pain after laparoscopic appendectomy

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• Subcostal TAP Block and EEG Changes During Laparoscopic Gallbladder Surgery

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  Recruiting Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Istanbul · NCT07818954

• Dexmedetomidine vs magnesium as intraperitoneal add-ons to bupivacaine for laparoscopic gallbladder removal

  This study tests whether adding dexmedetomidine or magnesium sulfate to bupivacaine injected inside the abdomen provides better pain relief after laparoscopic cholecystectomy for adults without serious health issues.

  Recruiting Alexandria University · Alexandria · NCT07693621

• How different ventilator settings affect lung energy during gallbladder surgery

  This study tests whether two ventilator modes (VCV and PRVC) deliver different amounts of energy to the lungs in adults undergoing laparoscopic gallbladder removal.

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Yenimahalle, Ankara · NCT07670494

• Erector Spinae Plane Block with Low-Flow Anaesthesia in Laparoscopic Cholecystectomy

  This trial tests whether a nerve block done before surgery plus very low-flow anesthesia reduces pain and opioid use after gallbladder removal.

  Recruiting Taksim Egitim ve Arastirma Hastanesi · Istanbul · NCT07653490

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.