Characterization of Within-Individual Resting Metabolic Rate Over 12 Weeks
Official title: Within-Individual Variability of Resting Metabolic Rate Assessed Repeatedly Over 12 Weeks Using Whole-Room Calorimetry
Run by Tel Aviv University · NCT07628764 · Data updated 2026-11-12
This study tests how an individual's resting metabolic rate varies when measured repeatedly over 12 weeks in healthy adults to understand true biology vs. measurement noise.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Tel Aviv University Academic / other |
| Locations | 1 site (Tel Aviv) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT07628764 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-65 who are healthy, with stable body weight (±2 kg) and able to attend three morning visits per week for 12 weeks.
✕Probably not a fit
Individuals with uncontrolled metabolic diseases, on medications affecting RMR, recent acute illness, pregnancy, or conditions interfering with participation may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study measures resting metabolic rate (RMR) three times per week for 12 weeks using whole-room indirect calorimetry under standardized conditions. The goal is to quantify within-person variability, separate biological variation from measurement error, and estimate the minimal detectable change for meaningful metabolic shifts. By collecting high-frequency data, the study aims to inform interpretation of longitudinal metabolic research and improve future study design. Participants are healthy adults aged 18-65 with stable weight, able to attend morning measurements regularly. No intervention will be applied beyond repeated RMR assessments.
Why it matters
Potential benefit: Findings could improve accuracy in interpreting changes in metabolic rate in future research and clinical assessments.
How similar studies have gone: Prior work suggests RMR can vary within individuals, but this high-frequency design will clarify the extent and structure of that variability.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18-65 years * Clinically healthy individuals * Stable body weight (±2 kg) over the past 3 months * Ability and willingness to attend morning measurements three times per week for 12 weeks * Ability to provide informed consent Exclusion Criteria: * Known uncontrolled endocrine or metabolic disease * Use of medications known to significantly affect resting metabolic rate (e.g., systemic corticosteroids, unstable thyroid hormone therapy) * Acute illness within 14 days prior to enrollment * Pregnancy or lactation * Any medical condition that, in the opinion of the investigators, may interfere with safe participation
Where it's running
-
Sylvan Adams Sport Science Institute
Tel Aviv, Israel Recruiting
Study contacts
- Principal investigator: Yftach Prof. Gepner — Tel Aviv University
- Study coordinator: Yftach Prof. Gepner
- Email: gepner@tauex.tau.ac.il
- Phone: +972 50-682-8501
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.