Examining how lactate moves in the blood during exercise
Transporte Eritrocitario de Lactato en Ejercicio
NA · Technical University of Madrid · NCT06104150
This study is testing how lactate moves in the blood during exercise and recovery to see how it affects both trained athletes and those who are less active, while also looking at the role of a specific gene.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 84 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | Technical University of Madrid (other) |
| Locations | 2 sites (Santander, Cantabria and 1 other locations) |
| Trial ID | NCT06104150 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the transport of lactate between plasma and erythrocytes during intervallic exercise and recovery, focusing on the influence of blood pH and the T1470A polymorphism of the SLC16A1 gene. The study consists of two phases: the first involves trained participants performing maximal and submaximal exercise tests, while the second phase quantifies MCT1 protein levels in erythrocyte membranes from both trained and sedentary individuals. The research aims to enhance understanding of lactate kinetics and the role of genetic factors in exercise performance.
Who should consider this trial
Good fit: Ideal candidates include trained individuals who exercise at least 5 hours per week and sedentary individuals who engage in minimal structured exercise.
Not a fit: Patients with any pathology affecting exercise performance or women with irregular menstrual cycles may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve exercise performance and recovery strategies for athletes and individuals engaging in physical activity.
How similar studies have performed: While some studies have explored lactate kinetics, this specific approach focusing on the T1470A polymorphism and its effects on MCT1 function during intervallic exercise is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI between 18 and 25 kg/m2 * Not smoker * In the case of trained participants: training at least 5 hours/week, of which at least 3 must be aerobic/anaerobic endurance training. Presentation of a medical certificate attesting to their medical fitness (capability) to perform intense physical exercise. * In the case of sedentary participants, less than 1 day of training per week or less than 2 hours of structured exercise per week. Exclusion Criteria: * Presenting any pathology that could impede the correct performance of the tests, or could influence the main study variables. * In the case of the female sample, having irregular menstrual cycles, oligomenorrhea or amenorrhea.
Where this trial is running
Santander, Cantabria and 1 other locations
- Laboratorio de Pediatría. School of Medicine. Univesidad de Cantabria — Santander, Cantabria, Spain (RECRUITING)
- Laboratorio de Fisiología del Esfuerzo. Facultad de Ciencias de la Actividad Física y del Deporte (INEF). Universidad Politécnica de Madrid — Madrid, Madrid, Spain (RECRUITING)
Study contacts
- Principal investigator: Rocío Cupeiro, PhD — Universidad Politecnica de Madrid
- Study coordinator: Rocío Cupeiro, PhD
- Email: rocio.cupeiro@upm.es
- Phone: +34910677990
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Energy Metabolism, lactate kinetics, MCT1, erythrocyte lactate, T1470A polymorphism, exercise