Examining how lactate moves in the blood during exercise
Official title: Transporte Eritrocitario de Lactato en Ejercicio
Run by Technical University of Madrid · NCT06104150 · Data updated 2026-11-12
This study is testing how lactate moves in the blood during exercise and recovery to see how it affects both trained athletes and those who are less active, while also looking at the role of a specific gene.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | All |
| Enrollment | 84 (estimated) |
| Sponsor | Technical University of Madrid Academic / other |
| Locations | 2 sites (Santander, Cantabria and 1 other locations) |
| Status | Recruiting |
| Started | February 3, 2020 |
| Main results expected | June 30, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | September 12, 2025 |
| Trial ID | NCT06104150 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include trained individuals who exercise at least 5 hours per week and sedentary individuals who engage in minimal structured exercise.
✕Probably not a fit
Patients with any pathology affecting exercise performance or women with irregular menstrual cycles may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the transport of lactate between plasma and erythrocytes during intervallic exercise and recovery, focusing on the influence of blood pH and the T1470A polymorphism of the SLC16A1 gene. The study consists of two phases: the first involves trained participants performing maximal and submaximal exercise tests, while the second phase quantifies MCT1 protein levels in erythrocyte membranes from both trained and sedentary individuals. The research aims to enhance understanding of lactate kinetics and the role of genetic factors in exercise performance.
Why it matters
Potential benefit: If successful, this study could improve exercise performance and recovery strategies for athletes and individuals engaging in physical activity.
How similar studies have gone: While some studies have explored lactate kinetics, this specific approach focusing on the T1470A polymorphism and its effects on MCT1 function during intervallic exercise is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI between 18 and 25 kg/m2 * Not smoker * In the case of trained participants: training at least 5 hours/week, of which at least 3 must be aerobic/anaerobic endurance training. Presentation of a medical certificate attesting to their medical fitness (capability) to perform intense physical exercise. * In the case of sedentary participants, less than 1 day of training per week or less than 2 hours of structured exercise per week. Exclusion Criteria: * Presenting any pathology that could impede the correct performance of the tests, or could influence the main study variables. * In the case of the female sample, having irregular menstrual cycles, oligomenorrhea or amenorrhea.
Where it's running
-
Laboratorio de Pediatría. School of Medicine. Univesidad de Cantabria
Santander, Cantabria, Spain Recruiting -
Laboratorio de Fisiología del Esfuerzo. Facultad de Ciencias de la Actividad Física y del Deporte (INEF). Universidad Politécnica de Madrid
Madrid, Madrid, Spain Recruiting
Study contacts
- Principal investigator: Rocío Cupeiro, PhD — Universidad Politecnica de Madrid
- Study coordinator: Rocío Cupeiro, PhD
- Email: rocio.cupeiro@upm.es
- Phone: +34910677990
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.