Liquid biopsy biomarkers to detect and monitor pancreatic cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes stored plasma samples to measure circulating cell-free and exosome-bound microRNAs. The goal is to see whether microRNA profiles can improve risk stratification and potentially predict disease progression beyond current imaging surveillance. No drugs or devices are used; the work relies on validated laboratory methods to quantify microRNA expression. Adults at increased PDAC risk due to family history or mucinous cysts, with available biospecimens and prior consent, are included. The study is conducted at IRCCS San Raffaele Hospital under the lead sponsor Università Vita-Salute San Raffaele.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult men or women aged ≥18 years at the time of plasma sample collection.
* Classification as at increased risk for pancreatic ductal adenocarcinoma (PDAC) due to familial pancreatic cancer or hereditary pancreatic cancer syndrome
* Classification as at increased risk for pancreatic ductal adenocarcinoma (PDAC) due to the presence of one (or more) mucinous pancreatic cystic lesion(s).
* Availability of stored plasma samples collected as part of routine clinical care or surveillance and archived in the institutional biobank.
* Availability of relevant clinical and demographic data in institutional medical records sufficient to address study objectives.
* Prior provision of informed consent for biobanking and research use of biological samples and data

Exclusion Criteria:

* Absence or insufficient quality/quantity of stored plasma samples for laboratory analysis.
* Lack of clinical data required for cohort classification and/or outcome assessment.
* History of pancreatic surgery or interventional procedures prior to plasma sample collection.
* Concurrent active malignancy at the time of sample collection, other than non-melanoma skin cancer.
* Samples collected outside routine clinical care or not compliant with institutional biobanking and data protection policies.

Where it's running

• IRCCS San Raffaele Hospital
  Milan, Mi, Italy Recruiting

Study contacts

• Principal investigator: Alessandro Mannucci, MD — Università Vita-Salute San Raffaele
• Study coordinator: Alessandro Mannucci, MD
• Email: mannucci.alessandro@hsr.it
• Phone: 0226437262

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.