Laparoscopic partial removal of the spleen for hypersplenism in cirrhosis.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Eligible patients with cirrhosis and hypersplenism were enrolled and randomly assigned 1:1 to either laparoscopic total splenectomy or laparoscopic partial splenectomy, with all operations performed by the same surgical team. The partial splenectomy technique preserved the short gastric vessels and splenic suspensory ligament and followed the intraoperative demarcation line. Postoperative care and medications were standardized and patients were followed at 7 days, and 1, 3, 6, and 12 months with routine blood tests, liver function, coagulation, immune markers, and vascular hemodynamics of the portal vein, proper hepatic artery, and splenic vein. Indocyanine green clearance tests were performed at 3, 6, and 12 months to track liver function over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A clinical, radiological or histologic diagnosis of cirrhosis of any etiology
* Splenomegaly with secondary hypersplenism
* gastroesophageal variceal bleeding
* Informed consent to participate in the study

Exclusion Criteria:

* Hepatocellular carcinoma or any other malignancy,
* Child-Pugh grade C
* Recent peptic ulcer disease
* History of Hemorrhagic stroke
* Pregnancy.
* Uncontrolled Hypertension
* Human immunodeficiency virus (HIV) infection

Where it's running

• Clinical Medical College of Yangzhou University
  Yangzhou, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Guo-Qing Jiang
• Email: jgqing2003@hotmail.com
• Phone: +8651487373382

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.