Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Influence of Sealer Composition on Post-Endodontic Pain

Official title: Influence of Sealer Composition on Post-Endodontic Pain: A Prospective Comparative Analysis of Three Root Canal Sealers

Run by Minia University · NCT07767084 · Data updated 2026-11-12

This study tests whether a calcium hydroxide–based sealer affects post-endodontic pain after primary root canal treatment in people with acute irreversible pulpitis.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment66 (estimated)
SponsorMinia University
Academic / other
Locations1 site (Minya)
StatusRecruiting
StartedApril 14, 2026
Main results expectedApril 1, 2027
Study endsApril 14, 2027
Registry record updatedAugust 17, 2026
Trial IDNCT07767084 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with acute irreversible pulpitis needing primary root canal treatment and no systemic health issues affecting healing.

Probably not a fit

Patients with systemic diseases affecting healing or those who had recent analgesic/antibiotic use may not experience benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Postoperative pain after endodontic therapy is common and can affect quality of life. This trial examines whether using a calcium hydroxide–based sealer influences the amount of pain patients experience after primary root canal treatment. Participants will be adults with acute irreversible pulpitis and good general health undergoing endodontic therapy. The study will assess postoperative pain levels in relation to sealer contact with periradicular tissues, considering factors like tooth type and preoperative pain. Findings could guide material choices to minimize postoperative discomfort.

Why it matters

Potential benefit: If effective, using the tested sealer could reduce early postoperative pain for patients undergoing root canal treatment.

How similar studies have gone: Previous research has suggested sealer composition can influence periradicular reactions, but results vary across settings and materials.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients requiring primary root canal treatment.
* Patients with acute irreversible pulpitis.
* Patients in good general health

Exclusion Criteria:

* Patients with systemic diseases affecting pain perception or healing.
* Patients who had taken analgesics or antibiotics within 12-24 hours prior to treatment.
* Pregnant or lactating women.
* Previously treated teeth or teeth with root resorption, fractures, or severe periodontal disease

Where it's running

  • Endodontics Department Faculty of Dentistry
    Minya, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.