Influence of Sealer Composition on Post-Endodontic Pain
Official title: Influence of Sealer Composition on Post-Endodontic Pain: A Prospective Comparative Analysis of Three Root Canal Sealers
Run by Minia University · NCT07767084 · Data updated 2026-11-12
This study tests whether a calcium hydroxide–based sealer affects post-endodontic pain after primary root canal treatment in people with acute irreversible pulpitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya) |
| Status | Recruiting |
| Started | April 14, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | April 14, 2027 |
| Registry record updated | August 17, 2026 |
| Trial ID | NCT07767084 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with acute irreversible pulpitis needing primary root canal treatment and no systemic health issues affecting healing.
✕Probably not a fit
Patients with systemic diseases affecting healing or those who had recent analgesic/antibiotic use may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Postoperative pain after endodontic therapy is common and can affect quality of life. This trial examines whether using a calcium hydroxide–based sealer influences the amount of pain patients experience after primary root canal treatment. Participants will be adults with acute irreversible pulpitis and good general health undergoing endodontic therapy. The study will assess postoperative pain levels in relation to sealer contact with periradicular tissues, considering factors like tooth type and preoperative pain. Findings could guide material choices to minimize postoperative discomfort.
Why it matters
Potential benefit: If effective, using the tested sealer could reduce early postoperative pain for patients undergoing root canal treatment.
How similar studies have gone: Previous research has suggested sealer composition can influence periradicular reactions, but results vary across settings and materials.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients requiring primary root canal treatment. * Patients with acute irreversible pulpitis. * Patients in good general health Exclusion Criteria: * Patients with systemic diseases affecting pain perception or healing. * Patients who had taken analgesics or antibiotics within 12-24 hours prior to treatment. * Pregnant or lactating women. * Previously treated teeth or teeth with root resorption, fractures, or severe periodontal disease
Where it's running
-
Endodontics Department Faculty of Dentistry
Minya, Egypt Recruiting
Study contacts
- Study coordinator: Nourhan Rabie Ahmed Ahmed, B.D.S
- Email: nourhan.rabie93@gmail.com
- Phone: +201148809567
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Preemptive multimodal pain control for pain after root canal therapy
This trial will test whether taking pregabalin or duloxetine together with acetaminophen before root canal treatment reduces immediate and longer‑term post‑endodontic pain in adults.
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This study is testing whether taking ibuprofen or dexamethasone before a root canal can help reduce pain afterward for people with severe tooth issues.
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Natural Biopolymer-Based Irrigant for Root Canal Cleaning
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This study tests three different medicaments placed inside the root canal between visits to see which best supports healing of periapical lesions in mature teeth.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.