Effect of Cyperus articulatus on bacterial reduction and postoperative pain in chronic apical periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines the addition of Cyperus articulatus essential oil as an intracanal medicament to improve disinfection during root canal therapy for necrotic teeth with chronic apical periodontitis. Participants are healthy adults with mandibular premolars diagnosed with necrotic pulp and radiographic signs of apical disease. The approach focuses on enhancing antimicrobial activity and reducing biofilm presence beyond conventional calcium hydroxide alone. Outcomes include bacterial reduction within the root canal system and reported postoperative pain. The study is conducted at the Endodontics Department of Minia University, led by Minia University with no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy adult Patient.
* Medically free patients.
* Mandibular permanent premolar teeth:

  * Diagnosed clinically with necrotic pulp.
  * Absence of pain.
  * Radiographic evidence of chronic apical periodontitis .
  * Radiographic evidence of single root with single canals.
  * Normal occlusal contact with opposing teeth.
* Patients' acceptance to participate in the trial.

Exclusion Criteria:

* Medically compromised patients having significant systemic disorders (ASA III or IV).
* If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.
* Pregnant women: to avoid radiation exposure, anaesthesia, medication and hormonal fluctuation that might increase pain prevalence.
* Patients reporting bruxism, clenching, TMJ problems or traumatic occlusion: to avoid further pressure on inflamed tooth which induce subsequent irritation and inflammation.
* Patients with two or more adjacent teeth requiring endodontic treatment.
* Teeth that requires further procedural steps or multidisciplinary approach, which is out of this experiment's scope:

  i. Association with swelling or fistulous tract. ii. Acute periapical abscess. iii. Mobility Grade II or III. iv. Pocket depth more than 5mm. v. Previous root canal treatment. vi. Non-restorable. vii. Immature root. viii. Radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification.
* Inability to perceive the given instructions.

Where it's running

• Endodontics Department Faculty of Dentistry,Minia University
  Minya, Egypt Recruiting

Study contacts

• Study coordinator: Fahd Mohamed Salah Hussien, B.D.S
• Email: fahd.mohamed@nub.edu.eg
• Phone: +201154959696

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• iRoot SP versus nRoot SP root canal sealers for chronic apical periodontitis

  This trial will test whether iRoot SP or nRoot SP root canal sealers produce better healing and less post-procedure pain in adults with chronic apical periodontitis.

  Recruiting The Dental Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT07388901

• Sonic versus passive ultrasonic irrigation for chronic root canal infection

  This trial will test whether sonic-activated irrigation or passive ultrasonic irrigation cleans infected root canals better in adults with chronic apical periodontitis.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07069881

• Different root canal sealers and salivary oxidative stress in chronic apical periodontitis.

  This test will compare two types of root canal sealers to see if they change saliva oxidative stress markers in adults with chronic apical periodontitis.

  Recruiting Ordu University · Ordu, Ordu- Altınordu · NCT07059481

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.