Three intracanal medicaments for mature teeth with periapical periodontitis
Official title: Evaluation of Three Different Intra-canal Medicaments on Postoperative Pain and Periapical Healing: Randomized Clinical Trial
Run by Minia University · NCT07892703 · Data updated 2026-11-12
This study tests three different medicaments placed inside the root canal between visits to see which best supports healing of periapical lesions in mature teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 45 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya) |
| Status | Recruiting |
| Started | December 16, 2025 |
| Main results expected | December 10, 2026 |
| Study ends | December 16, 2026 |
| Registry record updated | October 23, 2026 |
| Trial ID | NCT07892703 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with mature maxillary anterior teeth and a diagnosis of periapical periodontitis, without systemic diseases affecting healing, able to commit to one-year follow-up.
✕Probably not a fit
Patients with immature roots, systemic conditions, swelling, pregnancy, or inability to attend the one-year follow-up may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial examines the use of intracanal medicaments to improve healing of periapical lesions associated with mature teeth. Participants will have periapical periodontitis and undergo standard root canal treatment with an additional medicament between appointments. The goal is to determine which medicament—specifically Metapaste calcium hydroxide among the options—optimizes bacterial reduction, inflammation control, and healing outcomes. The study uses a single-center design at Minia University’s Department of Endodontics and follows patients for a one-year period. Outcomes focus on periapical healing and clinical resolution of symptoms.
Why it matters
Potential benefit: If successful, the medicament strategy could improve bacterial elimination and promote faster or more reliable periapical healing between endodontic treatment visits.
How similar studies have gone: Prior intracanal medicaments have shown reductions in bacterial load and improved healing, but this specific head-to-head comparison in mature teeth is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with mature teeth. * Patients with periapical periodontitis. * Maxillary anterior teeth only will be involved. * Patients should be free from any systemic disease that may affect normal healing and predictable outcome. * Patients who will agree to the consent and will commit to follow-up period. Exclusion Criteria: * Patients with immature roots. * Patients with any systemic disease that may affect normal healing. * Patients with swelling. * Pregnant females. * Patients who could/would not participate in a 1-year follow-up. 6-Patients with old age. * Teeth with periodontal involvement. 8-Teeth with vertical root fractures. * Non-restorable teeth. * cases with previously initiated endodontic treatment.
Where it's running
-
Department of Endodontics, Faculty of Dentistry Minia University
Minya, Egypt Recruiting
Study contacts
- Study coordinator: Shimaa Mohamed Abdelhamed, MSc
- Email: drshimamarof@gmail.com
- Phone: +201142155099
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing two medicines placed inside the root canal to help periapical lesions heal
This study will test whether placing calcium hydroxide or diclofenac sodium inside the root canal helps periapical lesions heal in adults having retreatment of single-rooted lower teeth.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.