Effect of anti-inflammatory drugs on pain after root canal treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of pre-medication with two anti-inflammatory drugs, ibuprofen and dexamethasone, on post-endodontic pain in patients with symptomatic irreversible pulpitis. A total of 130 patients will be screened and divided into two groups, with one group receiving ibuprofen and the other receiving dexamethasone 15 minutes prior to root canal treatment. The study will be conducted at the Armed Forces Institute of Dentistry, ensuring informed consent is obtained in the local language. The effectiveness of these medications will be assessed in relation to pain management following the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Permanent teeth with acutely inflamed pulp without swelling or draining sinus.
2. Patients of either gender aged between 18-50 years old.
3. Systemically healthy patients.
4. Patients who agree to attend for recall appointments and provide a written consent.

Exclusion Criteria:

1. Patients on preoperative analgesics and antibiotics.
2. Teeth with calcified canals and previously treated teeth.
3. Pregnant and lactating mothers.
4. Patients who are immunocompromised, anxious and mentally handicapped.
5. Patients who are allergic to any of the test medications.

Where it's running

• Armed Forces Institute Of Dentistry
  Rawalpindi, Pakistan Recruiting

Study contacts

• Principal investigator: Quratulain Abbasi, BDS — Afid
• Study coordinator: Quratulain Abbasi, BDS
• Email: quratulain.abbasi@gmail.com
• Phone: 00923315317467

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Dexamethasone and Spinal Block Duration in Lower Abdominal Surgery

  This study tests whether giving dexamethasone before spinal anesthesia can lengthen how long the numbness lasts for adults having lower abdominal surgery.

  Recruiting Phase 4 Holy Family Hospital, Pakistan · Rawalpindi, Punjab Province · NCT07819682

• Intraparotid injection of bupivacaine with dexamethasone after partial parotidectomy

  This early-phase study tests whether a single intraparotid injection of bupivacaine with dexamethasone is safe and tolerable after partial parotidectomy for a benign tumor.

  Recruiting Early Phase 1 Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT07812259

• Influence of Sealer Composition on Post-Endodontic Pain

  This study tests whether a calcium hydroxide–based sealer affects post-endodontic pain after primary root canal treatment in people with acute irreversible pulpitis.

  Recruiting Minia University · Minya · NCT07767084

• Olanzapine-based, dexamethasone-sparing antiemetic regimen for breast cancer patients with metabolic risk factors

  This study tests whether an olanzapine-containing antiemetic plan can match the usual dexamethasone-containing approach in preventing delayed chemotherapy-induced nausea and vomiting for breast cancer patients with metabolic risk factors.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07743827

• Liposomal Bupivacaine Plus Plain Bupivacaine vs Dexamethasone Plus Plain Bupivacaine for High-Risk Pain After Supraclavicular Brachial Plexus Block

  This trial tests whether liposomal bupivacaine with plain bupivacaine can better control postoperative pain after distal radial fracture surgery in patients at high risk of severe pain, compared with dexamethasone plus plain bupivacaine.

  Recruiting Phase 3 The University of Hong Kong · Hong Kong · NCT07665762

• Dexamethasone dosing for children with acute asthma in the emergency department

  This study tests whether two different single doses of dexamethasone given in the emergency department help children aged 4–15 during an asthma attack.

  Recruiting Phase 4 Sheffield Children's NHS Foundation Trust · Sheffield · NCT07402707

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.