Preemptive multimodal pain control for pain after root canal therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study compares preemptive multimodal analgesic regimens (pregabalin plus acetaminophen or duloxetine plus acetaminophen) against placebo given alongside standard endodontic care to adults with moderate to severe preoperative tooth pain. Participants who meet inclusion criteria will receive the assigned medication before undergoing non‑surgical or surgical endodontic procedures, with pain and sensory responses measured immediately and during follow‑up. Outcomes include immediate and chronic post‑endodontic pain, mechanical pain thresholds, and sensory testing, analyzed using chi‑square, t‑tests, and regression with Bonferroni correction for multiple comparisons. Placebo arms are included to help separate pharmacologic from psychological effects, and acetaminophen is available as rescue medication per protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient's aged 18 years more.
2. ASA physical status I-II.
3. Patient with the complain of pain originated from teeth and surrounding structure.
4. Preoperative pain severity is moderate to severe.
5. Patient can be able to make communication about their pain.
6. Patients give consent to attain this research.
7. Patients have others concomitant chronic pain.
8. Patients who will have non-surgical endodontic treatment.
9. Patients who will have non-surgical endodontic retreatment.
10. Patients who will have surgical endodontic treatment.

Exclusion Criteria:

1. Patient would not like to attain in research.
2. Patients have any medical condition those are contra indication for study drug.
3. ASA physical status III, IV, V.
4. Patient already under treated any anti convulsent drug.
5. Patient participant in other clinical trials.
6. Lack of motivation or poor adharence to study protocols.
7. Patient with Pregnancy
8. Severe organ dysfunction
9. Patient have Hepatitis B, and other cross infection disease like (HIV)
10. Uncontrolled comorbidities that patient do not fit for endodontic treatment.
11. Severe cognitive impaired patients.
12. History of certain cancers or severe hematological issues.

Where it's running

• Professor. Dr. Md. Abu Saeed Ibn Harun
  Chittagong, Chattogram, Bangladesh Recruiting

Study contacts

• Study coordinator: Prof.Dr. Md. Abu Saeed Ibn Harun, MS
• Email: dr.abusaeed@cidch.edu.bd
• Phone: 8801711157586

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Influence of Sealer Composition on Post-Endodontic Pain

  This study tests whether a calcium hydroxide–based sealer affects post-endodontic pain after primary root canal treatment in people with acute irreversible pulpitis.

  Recruiting Minia University · Minya · NCT07767084

• Effect of anti-inflammatory drugs on pain after root canal treatment

  This study is testing whether taking ibuprofen or dexamethasone before a root canal can help reduce pain afterward for people with severe tooth issues.

  Recruiting Phase 2 Armed Forces Institute of Dentistry, Pakistan · Rawalpindi · NCT06980870

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.