Combination treatment for chronic nasal obstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the efficacy and safety of combining oxymetazoline with intranasal corticosteroids for managing chronic nasal obstruction that does not respond to standard treatments. Participants will be randomized to receive either the combination treatment or corticosteroids alone over a 7-week period. They will apply the nasal spray twice daily and complete questionnaires to assess their symptoms. A subset of participants will also undergo nasal mucosal biopsies to evaluate treatment effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. males and females ages 18 years or older
2. have a history of nasal obstruction
3. have failed a trial of topical steroids (that included at least 1 month of daily use)
4. ability to read, write, and understand English
5. either do not desire surgery or are poor surgical candidates due to medical comorbidities.
6. Patients who have had prior use of oxymetazoline or other nasal decongestants are eligible for the study but must have stopped usage 4 weeks prior to randomization.

   1. Must be willing to stop using any other nasal sprays, besides saline, and oral decongestants.

Exclusion Criteria:

1. Any history of sinonasal mass/tumor
2. Any history of nasal polyps
3. a known history of chronic sinusitis
4. an allergy to oxymetazoline
5. or who have any medical contraindication to oxymetazoline use, such as pulmonary hypertension.

Where it's running

• Washington University
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Nyssa F Farrell, MD — Washington University School of Medicine
• Study coordinator: Nyssa Farrell, MD
• Email: nyssa.farrell@wustl.edu
• Phone: 314-362-7509

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.