Improving CT diagnostics for stroke mimics
The Importance of Multimodal CT Examination in Stroke Mimics Diagnosis: a Prospective Observational Multicenter Study
This study is testing new CT imaging methods to see if they can better identify patients who are having stroke-like symptoms but don’t actually have a stroke, helping to avoid unnecessary treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Ostrava Academic / other |
| Locations | 3 sites (Ostrava, Moravian-Silesian Region and 2 other locations) |
| Trial ID | NCT06045455 on ClinicalTrials.gov |
What this trial studies
This observational clinical research aims to enhance the accuracy of multimodal computer tomography (CT) diagnostics in identifying stroke mimics among patients with sudden neurological deficits. The study will involve patients over 18 years old who are suspected of having a stroke, utilizing advanced imaging techniques such as non-contrast CT, CT angiography, and CT perfusion. By comparing the effectiveness of these multimodal imaging methods against standard CT approaches, the study seeks to reduce inappropriate treatments and associated complications, while also analyzing the economic impact of improved diagnostics.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old presenting with acute focal neurological deficits within 24 hours of symptom onset.
Not a fit: Patients whose last period of normality is unknown or who have symptoms lasting more than 24 hours prior to examination may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of stroke mimics, reducing unnecessary treatments and improving patient outcomes.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for stroke diagnosis, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- an acute focal neurological deficit (minimum 1 point on the National Institutes of Health Stroke Scale - NIHSS) within 24 hours from the onset of symptoms Exclusion Criteria: * the last period of normality is unknown prior to multimodal CT examination * the last period of normality is \>24 hours prior to multimodal CT examination * the diagnostic evaluation is incomplete * a final neurologic diagnosis cannot be determined
Where this trial is running
Ostrava, Moravian-Silesian Region and 2 other locations
- University of Ostrava — Ostrava, Moravian-Silesian Region, Czechia (Recruiting)
- University Hospital Ostrava — Ostrava, Moravian-Silesian Region, Czechia (Recruiting)
- Hospital České Budějovice — České Budějovice, South Bohemian Region, Czechia (Recruiting)
Study contacts
- Principal investigator: Michal Bar, prof.,MD,PhD — University Hospital Ostrava
- Study coordinator: Jiří Hynčica
- Email: jiri.hyncica@fno.cz
- Phone: 0042059737
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.