Hyperbaric oxygen therapy for severe CRPS
Official title: Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome: a Randomised Controlled Trial
Run by University Hospital Ostrava · NCT07446712 · Data updated 2026-11-12
This trial tests whether adding hyperbaric oxygen therapy helps people with severe complex regional pain syndrome compared with a delayed-start approach.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University Hospital Ostrava Academic / other |
| Drugs / interventions | doxorubicin |
| Locations | 2 sites (Ostrava, Moravian-Silesian Region and 1 other locations) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | April 2028 |
| Study ends | April 2029 |
| Registry record updated | August 25, 2026 |
| Trial ID | NCT07446712 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with CRPS Type I (without nerve injury) who meet HBOT safety criteria and can provide informed consent.
✕Probably not a fit
Patients with contraindications to HBOT or those unlikely to benefit from this modality may not experience improvement.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, delayed-start study compares immediate versus delayed hyperbaric oxygen therapy in adults with CRPS Type I without nerve injury. The primary comparison occurs 4-6 weeks after baseline, with a secondary assessment after the delayed group's treatment. The study uses an early-treatment group and a wait-list control group to determine if HBOT provides additional benefit when added to standard care. Eligible participants must have CRPS Type I and meet safety criteria for HBOT. The trial is conducted at two hospitals in Ostrava, Czech Republic, led by University Hospital Ostrava with collaboration from Municipal Hospital Ostrava Fifejdy.
Why it matters
Potential benefit: If successful, patients may experience reduced pain and improved function from hyperbaric oxygen therapy.
How similar studies have gone: Previous studies of HBOT for CRPS have shown mixed but promising signals in some patients, though results vary by study design and population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Diagnosis of CRPS Type I (without nerve injury) Exclusion Criteria: * HBOT contraindications (pregnancy; use of bleomycin, cisplatin, disulfiram, and doxorubicin; middle ear surgery; untreated pneumothorax or pneumomediastinum; ongoing acute infection; severe decompensation of organ functions or organ failure, severe claustrophobia) * Inability to sign the consent form
Where it's running
-
University Hospital Ostrava
Ostrava, Moravian-Silesian Region, Czechia Recruiting -
Municipal Hospital Ostrava Fifejdy
Ostrava, Moravian-Silesian Region, Czechia Recruiting
Study contacts
- Principal investigator: Michal Hájek, MD, Ph.D., — Municipal Hospital Ostrava Fifejdy
- Study coordinator: Michal Hájek, MD, Ph.D.
- Email: michal.hajek@mnof.cz
- Phone: +42059619
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.