Identifying immune markers for cholera vaccine effectiveness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify correlates of protection (CoPs) for cholera, which are essential markers indicating an effective immune response to vaccination. Given the high incidence of cholera and the current vaccine shortages, establishing CoPs will facilitate the development and licensure of new cholera vaccines. Participants will receive either an oral cholera vaccine or a typhoid conjugate vaccine, and their immune responses will be monitored over a two-year period. The study seeks to address the critical gap in knowledge regarding effective immune responses to cholera vaccination.

Why it matters

Who can join: the full rules

Inclusion criteria

1. Ages 2 - 80 years.
2. Informed consent from study participants and guardian in case of children (2-17 years) and assent from children aged 11-17 years.
3. Intention to participate in the study for a 2-year period.
4. No major co-morbid conditions, per the supervising clinician investigator, including underlying immunodeficiency, diabetes, liver diseases, renal disease, cardiac disease, and/or active malignancy.

Exclusion criteria

1. Suffering from diarrhoea or abdominal pain or vomiting in the past 24 hours or diarrhoea lasting for more than 2 weeks in the past 6 months.
2. History of taking another oral cholera vaccine.
3. History of taking any other live or killed enteric vaccine in the last 8 weeks.

Where it's running

• Icddr,B
  Dhaka, Bangladesh Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Targeted water, sanitation, and hygiene intervention for cholera prevention

  This study is testing a new water, sanitation, and hygiene program to see if it can help people living near cholera patients stay healthy and reduce infections.

  Recruiting at 2 sites Johns Hopkins Bloomberg School of Public Health · Dhaka and 1 other locations · NCT06003816

• Preventing cholera through targeted water and hygiene interventions

  This study is testing a new way to improve water and hygiene practices for families of diarrhea patients in the Democratic Republic of the Congo to see if it can help prevent cholera.

  Recruiting at 2 sites Johns Hopkins Bloomberg School of Public Health · Bukavu, South Kivu and 1 other locations · NCT05166850

• Assessing the impact of cholera vaccination in endemic areas

  This study is testing if giving a cholera vaccine to lots of people in the Democratic Republic of the Congo can help keep cholera under control for at least two years.

  Recruiting Epicentre · Goma · NCT04853186

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.