Cholera control around a case area using targeted vaccination (CATI) in Dhaka

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial targets households around newly diagnosed cholera cases identified at icddr,b. Within a 20–40 meter radius of an index case, eligible household contacts receive oral cholera vaccine (OCV) with one or two doses given one month apart, alongside ongoing passive surveillance for cholera. The study also explores bacterial genome analysis and immune responses to V. cholerae from hotspots. Data on infection states and transmission within clusters will be tracked to assess impact on cumulative cholera incidence. The approach aims to provide rapid, localized vaccination as a potentially effective outbreak response.

Why it matters

Who can join: the full rules

Index case eligibility

Inclusion Criteria:

1. Some to severe dehydrated diarrheal patient
2. Provide signed informed consent form

Exclusion criteria:

1\. Resident in a ward already covered by OCV since 2015

Vaccination Eligibility

Inclusion Criteria:

1. Aged ≥1 year and non-pregnant
2. Meeting the definition of IHC and NHC
3. Provide signed informed consent form

Exclusion criteria:

1. History of taking OCV
2. Currently suffering from diarrhea
3. \< 1 year of age
4. Pregnant women (verbally confirmed)
5. Index case

Where it's running

• International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b)
  Dhaka, Bangladesh Recruiting

Study contacts

• Study coordinator: Dr. Fahima Chowdhury, MBBS, MPH, PhD
• Email: fchowdhury@icddrb.org
• Phone: +8801730016458

Similar studies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.