Assessing the impact of cholera vaccination in endemic areas
Cholera Control in Endemic Regions of Africa: Clinical Surveillance and Cholera Shedding Study in the Context of Mass Vaccination Campaigns, Democratic Republic of the Congo
This study is testing if giving a cholera vaccine to lots of people in the Democratic Republic of the Congo can help keep cholera under control for at least two years.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 6000 (estimated) |
| Sex | All |
| Sponsor | Epicentre Academic / other |
| Locations | 1 site (Goma) |
| Trial ID | NCT04853186 on ClinicalTrials.gov |
What this trial studies
This project evaluates the effectiveness of oral cholera vaccine mass campaigns in urban and rural areas of the Democratic Republic of the Congo (DRC). It includes clinical cholera surveillance to measure disease incidence, serological surveys to assess recent infection prevalence, and follow-up of individuals shedding V. cholerae. The goal is to determine if high vaccination coverage can sustain cholera control for at least two years. The findings will inform future cholera vaccination strategies in high-burden regions.
Who should consider this trial
Good fit: Ideal candidates include individuals presenting at selected Cholera Treatment Centers who meet the case definition and provide consent.
Not a fit: Patients who decline to participate in the study will not benefit from the findings.
Why it matters
Potential benefit: If successful, this study could lead to improved cholera vaccination strategies, reducing incidence and mortality in endemic areas.
How similar studies have performed: Other studies have shown success with cholera vaccination campaigns, indicating potential for positive outcomes in similar approaches.
Eligibility criteria
Show full inclusion / exclusion criteria
For Surveillance in study CTCs Inclusion Criteria: * All patients presenting at the time of the study to any selected Cholera Treatment Center/Cholera Treatment Unit (CTC/CTU), matching the case definition and giving his/her consent (or assent for children 8 to 17 years old) to participate in the study will be eligible. Exclusion Criteria: * Patients who decline to participate will be excluded from the study. Follow up of individuals with active cholera shedding: Inclusion Criteria: 1. present to any selected CTC/CTU, match the case definition, participate to the clinical surveillance activity and test positive to RDT OR 2. Be a household member of a person respecting inclusion criteria 1. AND for whom the head of the household has provided verbal consent to participate AND giving his/her consent (or assent for children 8 to 17 years old) to participate in the study will be eligible. Exclusion Criteria: \- Individuals who decline to participate will be excluded from the study, as well as households for whom the head of the household (and his or her representative) decline the participation of his/her household.
Where this trial is running
Goma
- Anais Broban — Goma, Democratic Republic of the Congo (Recruiting)
Study contacts
- Study coordinator: Anais BROBAN
- Email: anais.broban@epicentre.msf.org
- Phone: +33140215494
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.