L-PRF versus connective tissue graft with a customized healing abutment for immediate single-tooth implants
Evaluation of Soft and Hard Tissue Augmentation by Connective Tissue Graft or Leukocyte-Platelet Rich Fibrin in Immediate Implant Placement With Customized Healing Abutment: A Randomized Controlled Clinical Trial.
This will test whether using L-PRF or a connective tissue graft together with a customized healing abutment gives better soft- and hard-tissue outcomes for people receiving immediate single-tooth implants in the upper jaw.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 21 Years to 45 Years |
| Sex | All |
| Sponsor | Kafrelsheikh University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Kafr ash Shaykh, Kafrelsheikh) |
| Trial ID | NCT07102758 on ClinicalTrials.gov |
What this trial studies
This interventional comparison enrolls patients receiving immediate implants for non-restorable single-rooted maxillary centrals, canines, or premolars and treats the site with either L-PRF or an autologous connective tissue graft plus a customized healing abutment. Participants must have an intact labial/buccal bone plate, sufficient bone volume and width confirmed by CBCT, good oral hygiene, and be nonsmokers. Soft-tissue and hard-tissue outcomes such as gingival recession, soft-tissue thickness, and peri-implant bone levels will be recorded over follow-up visits using clinical measurements and imaging. The protocol excludes patients with insufficient bone, active infection, systemic diseases, pregnancy, or current cancer therapy.
Who should consider this trial
Good fit: Ideal candidates are nonsmoking adults with a single non-restorable maxillary central, canine, or premolar, an intact buccal bone plate and at least 1 mm of buccal bone width as confirmed by CBCT.
Not a fit: Patients with insufficient bone volume, active infection, uncontrolled systemic disease, ongoing chemotherapy or radiotherapy, pregnancy, bone disorders, periapical pathology, or smokers are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the preferred approach could improve soft tissue coverage and preserve buccal bone around immediate implants, enhancing esthetic outcomes and long-term implant stability.
How similar studies have performed: Previous clinical reports and small trials have shown promising but variable results for L-PRF and connective tissue grafting in immediate implant sites, so this comparison builds on existing but not definitive evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Intact labial/buccal bone plate
* The presence of non-restorable single-rooted maxillary centrals, canines or premolars.
* Sufficient bone volume.
* Good oral hygiene.
* Nonsmokers.
* Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).
Exclusion Criteria:
* Insufficient bone volume.
* Active infection.
* Patients on chemotherapy or radiotherapy.
* Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},
* Pregnant patients,
* Patients with bone diseases
* Presence of periapical pathology.
Where this trial is running
Kafr ash Shaykh, Kafrelsheikh
- Kafrelsheikh University — Kafr ash Shaykh, Kafrelsheikh, Egypt (Recruiting)
Study contacts
- Study coordinator: Ahmed Atef Salem, General doctor
- Email: dent.ahmedatef@gmail.com
- Phone: 0201007737797
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.