HRS-9190 vs Rocuronium for Muscle Relaxation During Anesthesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for elective surgery under general anesthesia are randomized to receive either HRS-9190 or rocuronium to produce neuromuscular blockade. The study measures how well each drug facilitates tracheal intubation, how quickly it works, how long its effects last, and recovery patterns. Safety is monitored through adverse events, vital signs, lab tests, and other safety indicators. Primary goal is to determine if HRS-9190 provides comparable or superior blockade for intubation with an acceptable safety profile. Secondary goals include onset time, duration of action, maintenance time during surgery, and recovery trajectory.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Able and willing to provide a written informed consent
2. Subjects requiring elective general anesthesia surgery
3. Meet specified age and body mass index (BMI) criteria
4. Conform to the ASA Physical Status Classification
5. Use of highly effective contraception for a specified period if applicable

Exclusion Criteria:

1. History of significant neuromuscular, cardiovascular, respiratory, or neurological disorders
2. History of conditions affecting drug metabolism or anesthesia risk
3. Abnormal laboratory values indicating significant clinical abnormalities
4. Positive serology for specified infectious diseases
5. Known hypersensitivity to related medications
6. Recent use of medications interfering with neuromuscular function
7. History of mental illness, cognitive impairment, or epilepsy
8. Participation in another clinical trial within a specified period
9. Any other condition deemed unsuitable by the investigator

Where it's running

• The Third Xiangya Hospital of Central South University
  Changsha, Hunan, China Recruiting
• The First Affiliated Hospital of Wenzhou Medical University
  Wenzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Lei Tang
• Email: lei.tang.lt31@hengrui.com
• Phone: +0518-81220121

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• NMTCuff vs standard TOF monitoring during gynecologic oncology surgery

  This study tests whether NMTCuff monitoring can better detect neuromuscular recovery than standard TOF monitoring in women undergoing laparoscopic gynecologic cancer surgery.

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Ankara · NCT07925463

• Two EMG Monitors for Deep NMB During Robotic/Thoracic Surgery

  This study tests whether two quantitative EMG monitors (TetraGraph and TwitchView) can better maintain deep neuromuscular blockade during abdominal and thoracic surgery by comparing diaphragmatic movements and breath-initiation events in the same patient.

  Recruiting Ohio State University · Columbus, Ohio · NCT07706504

• Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Monitoring

  This study tests whether keeping a low, controlled amount of rocuronium during spine surgery helps nerve monitoring while improving the surgical field compared to stopping rocuronium after induction.

  Recruiting Bach Mai Hospital · Hanoi, Hanoi · NCT07627750

• Safer muscle relaxant and reversal choice during anesthesia for people with chronic kidney disease

  This trial will try to see if using cisatracurium with neostigmine leads to fewer breathing problems after surgery than using rocuronium with sugammadex in adults who have chronic kidney disease.

  Recruiting Phase 4 The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07203287

• Comparing muscle responses for monitoring neuromuscular function after surgery

  This study is testing a device to see if it can better monitor muscle function after surgery for patients who have received a specific muscle relaxant.

  Recruiting University of Debrecen · Debrecen, Hajdú-Bihar and 1 other locations · NCT06691204

• Investigating neuromuscular blockade effects on pain after laparoscopic surgery in children

  This study tests if using different amounts of a muscle relaxant during laparoscopic surgery can help reduce pain in children aged 2 months to under 7 years after their operation.

  Recruiting Seoul National University Hospital · Seoul, Seoul · NCT06679569

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.