Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Monitoring
Official title: A Randomized Controlled Trial Comparing Low-Dose Rocuronium Maintenance Versus Discontinuation After Induction on Motor Evoked Potential Quality During Spine Surgery With Intraoperative Neurophysiological Monitoring
Run by Bach Mai Hospital · NCT07627750 · Data updated 2026-11-12
This study tests whether keeping a low, controlled amount of rocuronium during spine surgery helps nerve monitoring while improving the surgical field compared to stopping rocuronium after induction.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 62 (estimated) |
| Sponsor | Bach Mai Hospital Academic / other |
| Locations | 1 site (Hanoi, Hanoi) |
| Status | Recruiting |
| Started | October 7, 2026 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT07627750 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing spine surgery with intraoperative neurophysiological monitoring who consent to participate.
✕Probably not a fit
Patients who have pre-existing conditions affecting neurophysiological monitoring or who have safety concerns requiring avoidance of neuromuscular blockade may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares two rocuronium strategies during spine procedures with intraoperative neurophysiological monitoring. One group receives low-dose rocuronium titrated to maintain a train-of-four ratio between 0.60 and 0.90; the other group receives no maintenance after induction unless safety requires rescue. All patients receive standardized IV propofol-based anesthesia and quantitative neuromuscular monitoring. Primary outcome focuses on intraoperative motor evoked potential signal quality, with secondary outcomes including surgical field conditions, patient movement, emergence times, respiratory events, and new neurological deficits. The study is conducted at Bach Mai Hospital in Hanoi, Vietnam, with collaboration from Hanoi Medical University.
Why it matters
Potential benefit: If successful, the approach could improve the reliability of motor evoked potentials during spine surgery while potentially optimizing surgical conditions and recovery.
How similar studies have gone: Prior work suggests neuromuscular blockade levels can impact evoked potentials and monitoring quality, but evidence for this exact titration strategy is limited and this trial aims to clarify.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years or older. * Patients scheduled for spine surgery under general anesthesia. * Patients undergoing spine surgery with intraoperative neurophysiological monitoring, including motor evoked potentials and/or somatosensory evoked potentials. * Patients who agree to participate in the study and provide written informed consent. Exclusion Criteria: * Pre-existing central or peripheral neurological disease that may affect intraoperative neurophysiological monitoring, such as quadriplegia, persistent sensory disorder, sequelae of stroke, or polyneuropathy. * History of epilepsy or electroencephalographic disorder. * Use of neuropsychiatric drugs, strong sedatives, or drugs affecting neuromuscular or neurological conduction within 48 hours before surgery. * Decompensated cardiovascular disease or severe respiratory disease that may affect emergence or anesthetic drug metabolism. * Contraindication to intraoperative neurophysiological monitoring. * Contraindication to rocuronium. * Refusal to participate or withdrawal of consent at any time.
Where it's running
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Bach Mai Hospital
Hanoi, Hanoi, Vietnam Recruiting
Study contacts
- Principal investigator: Toan Thang Nguyen, MD, PhD, Associate Professor — Hanoi Medical University
- Study coordinator: Duc Minh Tran, MD
- Email: tdminh1312@gmail.com
- Phone: 84869319291
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.