Autogenous Palatal Graft Effects on Peri-implant Mucosa During Second-Stage Implants
Official title: Clinical, Radiographic, and Digital Evaluation of the Effects of Autogenous Grafts Harvested From Different Palatal Sites and Applied During Second-stage Implant Surgery on the Peri-implant Mucosa
Run by Kutahya Health Sciences University · NCT07330609 · Data updated 2026-11-12
This study tests whether grafts taken from different parts of the palate can improve the soft tissue around dental implants in adults who are already receiving a second-stage implant procedure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Months and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Kutahya Health Sciences University Academic / other |
| Locations | 1 site (Kütahya, Merkez) |
| Status | Recruiting |
| Started | February 2, 2026 |
| Main results expected | August 2, 2027 |
| Study ends | November 1, 2027 |
| Registry record updated | July 28, 2026 |
| Trial ID | NCT07330609 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 who are systemically healthy, have a mandible premolar or molar loss, and meet specific bone and tissue criteria for implant placement.
✕Probably not a fit
Patients with poor oral hygiene, uncontrolled periodontal disease, pregnancy, uncontrolled diabetes, or compromised immune status may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial explores how coronal and apical palatal tissue grafts affect the width and thickness of peri-implant mucosa using clinical, radiographic, and digital assessments. It also looks at the health of the peri-implant tissue and patient-reported outcomes to compare grafting techniques during peri-implant soft tissue management. Participants are adults with mandibular premolar or molar loss who are undergoing dental implant placement, and results will help determine if graft location influences tissue healing and stability.
Why it matters
Potential benefit: If successful, the approach could lead to better soft-tissue results around implants and potentially improve implant longevity and aesthetics.
How similar studies have gone: Prior research on autogenous palatal grafts has shown variable but promising improvements in peri-implant soft tissue characteristics in selected scenarios.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years * Systemically healthy patients * Presence of premolar or molar tooth loss in the mandible * Adequate mesiodistal and interocclusal space for implant and restoration placement * At least four months elapsed since tooth extraction * Alveolar bone width of at least 6 mm and sufficient alveolar bone height to allow implant placement without compromising anatomical structures * Full-mouth plaque and bleeding scores less than 20% * Presence of opposing teeth in occlusion * Keratinized mucosa width in the relevant region less than 2 mm * Keratinized mucosa thickness in the relevant region of 2 mm or less * Presence of a healthy second premolar in the maxilla * Provision of written informed consent and permission for the use of data for research purposes Exclusion Criteria: * Poor oral hygiene * Uncontrolled periodontal disease * Pregnancy or lactation at any stage of the study * Uncontrolled diabetes mellitus * Immunocompromised patients * Previous radiotherapy to the head and neck region * Diseases or medications affecting bone metabolism * Antibiotic use within the three months prior to the procedure * Smoking more than 10 cigarettes per day * Pre- or simultaneous bone augmentation prior to implant placement * Lack of primary stability at the time of implant placement
Where it's running
-
Kutahya Health Sciences University
Kütahya, Merkez, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ezgi Gürbüz
- Email: ezgi.dogan@ksbu.edu.tr
- Phone: +905557411860
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.