Targeted Lens Intervention for Anisometropia in Children
Official title: Clinical Investigation of Targeted Lens Intervention in the Management of Myopic Anisometropia in Children
Run by Essilor International · NCT07533149 · Data updated 2026-11-12
We’re testing if research spectacles can reduce the difference in prescription between a child’s eyes when one eye is more myopic than the other.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years to 13 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Essilor International Industry-sponsored |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | August 13, 2026 |
| Main results expected | November 2027 |
| Study ends | November 2027 |
| Registry record updated | September 15, 2026 |
| Trial ID | NCT07533149 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children 6–12 years old with anisometropic myopia (SER difference ≥1.0 D) and good visual acuity.
✕Probably not a fit
Children without anisometropia, with high corneal astigmatism, or with other ocular diseases may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study will enroll children aged 6 to under 13 with anisometropic myopia to wear specially designed study spectacles. Researchers will monitor changes in axial length and refractive error over time, using cycloplegic measurements to assess prescription accuracy. Participants will visit the Essilor R&D Centre and a clinical site for follow-up visits over a 12-month period. Data will help determine whether the spectacles can harmonize vision between eyes in this population.
Why it matters
Potential benefit: If successful, the intervention could reduce inter-eye refractive differences and stabilize eye growth in children with anisometropic myopia.
How similar studies have gone: Prior studies in myopia control have explored lenses and spectacles; this approach is a targeted, child-specific approach and its novelty/established success is evolving.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Voluntary 2. Informed consent of parent/guardian and assent of participant 3. Age equal to or greater than 6 years old and less than 13 years at the time of signing informed consent and assent 4. SER equal or less than -0.50 D and equal or greater than .5.00 D with astigmatism not more than 2.50 D 5. Difference in SER (anisometropia) between two eyes .1.00 D 6. Best corrected visual acuity (BCVA) better than or equal to +0.20 LogMAR in each eye 7. Agree to wear study spectacles for .12 hours/day and 7 days/week 8. Willingness and ability to participate in investigation for 12 months and attend scheduled visits punctually 9. Agree for no concurrent involvement in other myopia control treatment Exclusion Criteria: 1. History or presence of an ocular disease affecting refractive status 2. History or presence of strabismus 3. Presence of amblyopia 4. Current or previous use of atropine and/or orthokeratology 5. Known allergy to cycloplegic agents 6. Contraindication to cycloplegic agents 7. Cognitive or psychological vulnerability
Where it's running
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Essilor R&D Centre Singapore
Singapore, Singapore Recruiting
Study contacts
- Principal investigator: Theophila Ang — Essilor R&D Centre Singapore
- Study coordinator: Celine Carimalo
- Email: carimalc@essilor.com.sg
- Phone: +65 6589 9216
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.