Exercise to slow down cardiovascular ageing
Official title: Exercise to Slow Cardiovascular Ageing Progression
Run by National Heart Centre Singapore · NCT05775484 · Data updated 2026-11-12
This study tests if an exercise program can help older adults slow down heart aging and lower their risk of heart disease compared to those who don’t exercise.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years to 100 Years |
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | National Heart Centre Singapore Academic / other |
| Locations | 1 site (Singapore, Singapore) |
| Status | Recruiting |
| Started | May 1, 2023 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2050 |
| Registry record updated | June 5, 2025 |
| Trial ID | NCT05775484 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 21 and older who are able to walk outdoors.
✕Probably not a fit
Patients who are wheelchair or bed-bound, have dementia, or suffer from uncontrolled chronic conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how exercise may influence cardiovascular ageing and reduce the risk of cardiovascular disease in older adults. Participants will be randomly assigned to either an exercise program or a control group with no exercise. The study will assess cardiovascular structure and function through imaging and metabolic profiling at the beginning and end of the study. The goal is to determine if exercise can modify high-risk metabolic profiles associated with cardiovascular ageing.
Why it matters
Potential benefit: If successful, this study could provide evidence that exercise can significantly reduce the risk of cardiovascular disease in older adults.
How similar studies have gone: Other studies have shown promising results in using exercise to improve cardiovascular health, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>=21 years old * Outdoor ambulant Exclusion Criteria: * Wheelchair or bed-bound * Dementia * Residing in sheltered or nursing home * Cancer * Participation in ongoing clinical trials that involve interventional drugs or devices * Aneurysms * Acute infections (in the last six months) * Uncontrolled thyrotoxicosis * Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise * Uncontrolled asthma or chronic lung disease * Restrictive lung disease
Where it's running
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National Heart Centre Singapore
Singapore, Singapore, Singapore Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.