Personalized interventions for older adults with cardiac frailty
Official title: Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Cardiac Frailty
Run by National Heart Centre Singapore · NCT05946174 · Data updated 2026-11-12
This study is testing personalized exercise and diet plans to see if they can help older adults with heart problems feel better and improve their health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 100 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | National Heart Centre Singapore Academic / other |
| Locations | 6 sites (Singapore and 5 other locations) |
| Status | Recruiting |
| Started | July 12, 2023 |
| Main results expected | June 21, 2028 |
| Study ends | June 21, 2028 |
| Registry record updated | June 5, 2025 |
| Trial ID | NCT05946174 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are older adults aged 21 and above who are ambulant and diagnosed with cardiac frailty.
✕Probably not a fit
Patients who are bed-bound, have severe cognitive impairments, or are suffering from advanced chronic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop targeted exercise and dietary interventions for older adults suffering from cardiac frailty, a condition exacerbated by cardiovascular diseases. Over five years, up to 500 participants will be randomized to receive either specialized intervention sets or usual care across various healthcare settings. The first phase focuses on implementing these interventions in inpatient and outpatient environments, while the second phase will scale up successful programs. The interventions will address both exercise training and nutritional needs specific to cardiac conditions.
Why it matters
Potential benefit: If successful, this study could significantly improve the health and quality of life for older adults with cardiac frailty by providing tailored interventions.
How similar studies have gone: Other studies have shown promise in using tailored interventions for frailty, but this specific approach targeting cardiac frailty is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 21 years old * Outdoor ambulant Exclusion Criteria: 1. Bed-bound 2. Dementia (Stage 6 onwards) 3. Residing in sheltered or nursing home 4. Cancer (to avoid confounding with cardiac disease sequelae from cancer) 5. Participation in ongoing clinical trials that involve interventional drugs or devices 6. Uncontrolled hypertension (systolic blood pressure ≥160mmHg and/or diastolic blood pressure ≥90mmHg) despite being on treatment for hypertension 7. Low blood pressure (systolic blood pressure \<90mmHg or diastolic blood pressure \<40mmHg) 8. Uncontrolled atrial fibrillation (controlled atrial fibrillation is allowed) 9. Ventricular arrhythmias (such as ventricular tachycardia) 10. Renal failure on dialysis 11. Chronic kidney disease Stage 4 and above 12. Nephrotic syndrome 13. Liver cirrhosis Child's B and above 14. Inflammatory Bowel Disease 15. Severe uncontrolled gout 16. Poorly controlled Diabetes Hba1c ≥9% 17. On warfarin 18. Presence of food allergies (such as shell-fish, prawn) 19. Patient's life expectancy is expected to be less than one year at the time of potential enrolment as assessed by the investigator 20. Nasogastric or parenteral nutrition 21. Hypertrophic cardiomyopathy 22. Cardiac amyloidosis 23. Cardiac sarcoidosis
Where it's running
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Alexandra Hospital
Singapore, Singapore Recruiting -
National Heart Centre Singapore
Singapore, Singapore Recruiting -
Changi General Hospital
Singapore, Singapore Recruiting -
Sengkang General Hospital
Singapore, Singapore Recruiting -
Jurong Community Hospital
Singapore, Singapore Recruiting -
NHG Polyclinics
Singapore, Singapore Recruiting
Study contacts
- Principal investigator: Angela Su-Mei Koh, MBBS, MPH — National Heart Centre Singapore
- Study coordinator: Angela Su-Mei Koh
- Email: angela.koh.s.m@singhealth.com.sg
- Phone: +65 6704 8961
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.