Cardiovascular and Cognitive Health Initiative

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study examines how memory and thinking are affected in people with cardiovascular disease and whether early detection plus structured interventions can improve cognitive outcomes. It uses a structured approach combining cognitive and cardiovascular care to identify prevalence and profiles of cognitive impairment in this population. An RCT sub-study in mild cognitive impairment will compare cognitive test improvements at 24 weeks between the intervention and usual care arms. Secondary outcomes include changes in memory, processing speed, mental health, frailty, quality of life, and links between cognitive status and cardiovascular treatment plans. The research involves adult participants from three Singaporean hospitals under the National Heart Centre Singapore as lead sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Main Study:

* Age ≥ 21 years.
* Able and willing (or via legally acceptable representative, LAR, where appropriate) to provide informed consent.

RCT Sub-Study (Mild cognitive impairment (MCI) arm):

* Meets main study criteria.
* Mild cognitive impairment defined by: (i) Montreal cognitive assessment (MoCA) \<26 but ≥21; and/or (ii) impairment in at least one domain on standardized neuropsychological testing and/or (iii) MMSE \<28 but ≥24.

Exclusion Criteria:

* Neurodegenerative disorders or major psychiatric illnesses that substantially impair cognition.
* Terminal illness or advanced major organ disease limiting participation with expected survival of less than 1 year.
* Severe depression, anxiety, or stress where participation may be inappropriate.
* Any condition which, in the investigator's opinion, would compromise safety or study integrity.

Note: Pregnant and breast-feeding women may not take part in this study.

Where it's running

• National Heart Centre Singapore
  Singapore, Singapore Recruiting
• Alexandra Hospital
  Singapore, Singapore Not yet recruiting
• Khoo Teck Puat Hospital
  Singapore, Singapore Not yet recruiting
• Sengkang General Hospital
  Singapore, Singapore Not yet recruiting

Study contacts

• Study coordinator: Angela S. Koh, MBBS
• Email: angela.koh.s.m@singhealth.com.sg
• Phone: +6567048961

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.