Understanding genetic factors in young adults with heart attacks

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the genetic variants associated with acute myocardial infarction (AMI) in young adults, particularly those under 60 years old who may not exhibit traditional cardiovascular risk factors. By utilizing advancements in genomics, metabolomics, and proteomics, the study seeks to uncover novel insights into the underlying causes of AMI in this demographic. Participants will undergo blood draws to analyze their genetic and molecular profiles, contributing to a better understanding of cardiovascular disease in Asian populations, which have been underrepresented in previous research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult \>21 years old.
2. Age ≤50 years old irrespective of the presence of CV risk factors\* at the time of myocardial infarction OR Age 51-60 years old with no more than 2 CV risk factor\* at the time of myocardial infarction, excluding diabetes mellitus
3. Able to provide informed consent.
4. Patients who are willing and able to comply with the study visit and procedures.
5. Prior type 1 myocardial infarction with angiographically/CT documented significant stenosis of ≥50% in LM or ≥70% in major epicardial/branch vessel (e.g. LAD, LCX, RCA).
6. Patients who are from the three main races (Chinese, Malay, Indian). Race is self-identified by patient.

   * Hypertension, hyperlipidemia, diabetes mellitus, obesity, current smoker

Exclusion Criteria:

1. Known familial hypercholesterolaemia, known vasculitides, end-stage renal disease and congenital heart disease.
2. Prior PAD and Stroke
3. Female patients who are pregnant
4. Patients who are non-Asian

Where it's running

• National Heart Centre Singapore
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Jonathan Yap — National Heart Centre Singapore
• Study coordinator: Tze Theng Goh
• Email: goh.tze.theng@nhcs.com.sg
• Phone: 67042227

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.