Understanding genetic factors in young adults with heart attacks
UNdeRstAnding Novel Variants in AcutE MyocardiaL Infarction in Young Adults
This study is trying to find out how genetics might play a role in heart attacks for young adults under 60 who don’t have typical heart disease risk factors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Sponsor | National Heart Centre Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT06698341 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic variants associated with acute myocardial infarction (AMI) in young adults, particularly those under 60 years old who may not exhibit traditional cardiovascular risk factors. By utilizing advancements in genomics, metabolomics, and proteomics, the study seeks to uncover novel insights into the underlying causes of AMI in this demographic. Participants will undergo blood draws to analyze their genetic and molecular profiles, contributing to a better understanding of cardiovascular disease in Asian populations, which have been underrepresented in previous research.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21-60 years with a history of myocardial infarction and specific cardiovascular risk profiles.
Not a fit: Patients with known familial hypercholesterolemia, congenital heart disease, or those who are non-Asian may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification and prevention strategies for acute myocardial infarction in young adults.
How similar studies have performed: While there have been studies on cardiovascular genetics, this approach focusing on young adults in Asian populations is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult \>21 years old. 2. Age ≤50 years old irrespective of the presence of CV risk factors\* at the time of myocardial infarction OR Age 51-60 years old with no more than 2 CV risk factor\* at the time of myocardial infarction, excluding diabetes mellitus 3. Able to provide informed consent. 4. Patients who are willing and able to comply with the study visit and procedures. 5. Prior type 1 myocardial infarction with angiographically/CT documented significant stenosis of ≥50% in LM or ≥70% in major epicardial/branch vessel (e.g. LAD, LCX, RCA). 6. Patients who are from the three main races (Chinese, Malay, Indian). Race is self-identified by patient. * Hypertension, hyperlipidemia, diabetes mellitus, obesity, current smoker Exclusion Criteria: 1. Known familial hypercholesterolaemia, known vasculitides, end-stage renal disease and congenital heart disease. 2. Prior PAD and Stroke 3. Female patients who are pregnant 4. Patients who are non-Asian
Where this trial is running
Singapore
- National Heart Centre Singapore — Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Jonathan Yap — National Heart Centre Singapore
- Study coordinator: Tze Theng Goh
- Email: goh.tze.theng@nhcs.com.sg
- Phone: 67042227
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.