Asia‑Pacific registry of mitral and tricuspid valve‑in‑valve and valve‑in‑ring procedures
Official title: The Asia-Pacific Mitral & Tricuspid Valve-in-Valve/Valve-in-Ring Registry (AP ViV Registry)
Run by National Heart Centre Singapore · NCT07058935 · Data updated 2026-11-12
Collecting medical data from adults across the Asia‑Pacific who have had—or plan to have—mitral or tricuspid valve‑in‑valve or valve‑in‑ring procedures with a balloon‑expandable valve to see how patients do.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | National Heart Centre Singapore Academic / other |
| Locations | 8 sites (New Lambton Heights and 7 other locations) |
| Status | Recruiting |
| Started | March 17, 2025 |
| Main results expected | December 2035 |
| Study ends | December 2035 |
| Registry record updated | July 10, 2025 |
| Trial ID | NCT07058935 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 21 or older who have already undergone, or are scheduled to undergo, a mitral or tricuspid valve‑in‑valve or valve‑in‑ring procedure with a balloon‑expandable valve at a participating Asia‑Pacific site are eligible.
✕Probably not a fit
Patients with active endocarditis or other medical conditions that investigators deem unsuitable are excluded and unlikely to benefit from inclusion in the registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicenter, observational cohort collecting both retrospective and prospective consecutive cases of transcatheter mitral and tricuspid valve‑in‑valve (ViV) and valve‑in‑ring (ViR) procedures performed with balloon‑expandable valves across participating Asia‑Pacific sites. Retrospective data include procedures from January 1, 2023 to the present, and prospective enrollment captures planned procedures going forward. Core clinical, procedural, and outcome data will be recorded to describe real‑world practice and patient outcomes. No investigational treatment is assigned and local investigators determine suitability for inclusion.
Why it matters
Potential benefit: If successful, the registry could provide real‑world outcome data that help clinicians refine patient selection and procedural planning for mitral or tricuspid ViV/ViR procedures.
How similar studies have gone: Other regional and international ViV/ViR registries have reported procedural feasibility and helped characterize outcomes, so this approach builds on existing, partly successful registry work rather than being wholly novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 21 2. Had at least one documented Mitral valve-in-valve/valve-in-ring procedure done during the period of 1 Jan 2023 to current date. (Retrospective) OR Planned to undergo a Mitral valve-in-valve/valve-in-ring procedure. (Prospective) OR Had at least one documented Tricuspid valve-in-valve/valve-in-ring procedure done during the period of 1 Jan 2023 to current date. (Retrospective) OR Planned to undergo a Tricuspid valve-in-valve/valve-in-ring procedure. (Prospective) Exclusion Criteria: 1. Active endocarditis 2. Any other conditions which investigator deems unsuitable for participation.
Where it's running
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National Heart Centre Singapore
Singapore, Singapore Recruiting -
John Hunter Hospital
New Lambton Heights, Australia Not yet recruiting -
Prince of Wales Hospital
Hong Kong, Hong Kong Not yet recruiting -
Queen Elizabeth Hospital
Hong Kong, Hong Kong Not yet recruiting -
MGM Healthcare Pvt Ltd
Chennai, Tamil Nadu, India Not yet recruiting -
The Madras Medical Mission
Chennai, Tamil Nadu, India Not yet recruiting
Show 2 more locations
-
Waikato Hospital
Hamilton, New Zealand Not yet recruiting -
Ramathibodi Hospital
Bangkok, Thailand Not yet recruiting
Study contacts
- Study coordinator: Deborah Yip
- Email: deborah.yip.x.y@singhealth.com.sg
- Phone: +65-67042301
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.