Evaluating Propofol Dosing in Obese Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the dosing of propofol, an intravenous anesthetic, based on total body weight in morbidly obese patients undergoing surgery. It aims to address the challenges of drug accumulation and potential overdosing that can occur when using standard dosing methods. The study will compare the effectiveness of dosing based on total body weight versus adjusted body weight for maintaining anesthesia during procedures lasting over 60 minutes. By focusing on the unique pharmacokinetics in obese patients, the study seeks to improve anesthesia management and patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ASA physical status II/III
2. laparoscopic and non-laparoscopic surgery of more than 60-minutes duration
3. Body mass index \> 35kg/m2

Exclusion Criteria:

1. Cardiovascular disorders (uncontrolled hypertension, Atrio-ventricular block, sinus bradycardia, congenital heart disease, reduced LV compliance \& diastolic dysfunction)
2. Neurological disorders (previous neurosurgery, psychiatric disorders, autonomic nervous system disorders- orthostatic hypotension, transient ischemic attacks)
3. Hepato-renal insufficiency
4. Uncontrolled diabetes mellitus
5. Known allergy/hypersensitivity to study drug
6. Pulmonary dysfunction (restrictive /obstructive lung disease)
7. Acute/chronic drug dependence/substance abuse

Where it's running

• Nitin Sethi
  New Delhi, National Capital Territory of Delhi, India Recruiting

Study contacts

• Study coordinator: Nitin Sethi, DNB
• Email: nitinsethi77@yahoo.co.in
• Phone: +919717494498

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.