Propofol-Ketamine vs Sevoflurane for anesthesia in kids undergoing heart catheterization
Official title: COMPARISON OF PROPOFOL AND KETAMINE WITH SEVOFLURANE FOR LARYNGEAL MASK ANESTHESIA FOR CARDIAC CATHETERIZATION OF PEDIATRIC PATIENTS AT RAWALPINDI INSTITUTE OF CARDIOLOGY, RAWALPINDI
Run by Rawalpindi Institute of Cardiology · NCT07907796 · Data updated 2026-11-12
In children needing a heart catheterization, doctors compare using propofol-ketamine versus sevoflurane to see which anesthesia approach is safer and helps kids wake up smoothly.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 2 Years to 12 Years |
| Sex | All |
| Enrollment | 68 (estimated) |
| Sponsor | Rawalpindi Institute of Cardiology Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | October 24, 2026 |
| Main results expected | January 24, 2027 |
| Study ends | January 25, 2027 |
| Registry record updated | October 30, 2026 |
| Trial ID | NCT07907796 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children 10–30 kg with ASA I–III undergoing cardiac catheterization and no significant drug allergies or respiratory/hepatic/renal dysfunction.
✕Probably not a fit
Children outside the 10–30 kg range, with higher risk conditions, or with excluded airway or organ dysfunction may not benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, interventional study assigns pediatric patients weighing 10–30 kg and ASA I–III to receive either IV propofol-ketamine or inhaled sevoflurane to achieve adequate anesthesia during cardiac catheterization. Anesthesia depth is guided by continuous infusion of propofol and ketamine or by a sevoflurane MAC target, with the time to loss of consciousness recorded. After the procedure, metrics such as time to LMA removal, recovery duration, and emergence delirium at multiple time points in recovery are collected, with delirium treated if appropriate.
Why it matters
Potential benefit: If successful, the study could identify the approach that provides faster recovery and fewer agitation events, improving comfort and safety for children undergoing this procedure.
How similar studies have gone: Previous studies in pediatric anesthesia have explored different agents for catheterization, suggesting this comparison is feasible though specific combination data may be limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Weighing 10-30kg * ASA I-III of either sex * Undergoing cardiac catheterization Exclusion Criteria: * History of Drug Allergy * Pre-existing Asthma * Renal or Hepatic dysfunction * Difficult/prolonged intubation * Congenital airway abnormalities
Where it's running
-
Rawalpindi Institute of Cardiology
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Nasreen Qaisrani, MBBS
- Email: drnasreenqaisrani@gmail.com
- Phone: +92-3317318740
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.