Comparing Minto and Eleveld remifentanil target-controlled infusion models during general anesthesia
Official title: Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison Through qNOX and ANIi Reactions to Post-tetanic Count
Run by University of Padova · NCT07259291 · Data updated 2026-11-12
This study tests whether the newer Eleveld remifentanil infusion model gives similar effect-site concentrations for pain control as the commonly used Minto model in adults having general anesthesia with propofol.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | University of Padova Academic / other |
| Locations | 1 site (Treviso) |
| Status | Recruiting |
| Started | November 25, 2025 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | June 8, 2026 |
| Trial ID | NCT07259291 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for general anesthesia using target-controlled infusions of propofol (Eleveld model) and remifentanil (Minto or Eleveld) without neurological or psychiatric disease are ideal candidates.
✕Probably not a fit
Patients with neurological or psychiatric disorders, children, or anyone not receiving TCI of propofol and remifentanil are unlikely to benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Remifentanil, a short-acting opioid, is commonly delivered by target-controlled infusion (TCI) using pharmacokinetic/pharmacodynamic models to maintain a desired effect-site concentration. This observational study compares the routinely used Minto model with the more recently developed Eleveld model by recording predicted remifentanil effect-site concentrations (CeR) and correlating them with nociception measures including qNOX (CONOX monitor), Analgesia Nociception Index (ANI), and post-tetanic count during maintenance. Participants receive propofol TCI using the Eleveld propofol model and remifentanil via either the Minto or Eleveld remifentanil model while standard monitoring is performed. The goal is to determine whether the two models require different CeR to achieve similar analgesic/nociceptive readouts.
Why it matters
Potential benefit: If the Eleveld model better matches nociception signals, it could help clinicians dose remifentanil more accurately and reduce under- or over-dosing during anesthesia.
How similar studies have gone: The Minto model is well established in clinical practice while the Eleveld model is newer and based on large pooled datasets, but direct head-to-head clinical comparisons remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and Remifentanil (Minto or Eleveld model) Exclusion Criteria: * Neurological disease * Psychiatric disease
Where it's running
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ULSS2 Marca Trevigiana
Treviso, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.