Evaluating genetic causes of out-of-hospital cardiac arrest
Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to Families
This study is trying to find out if genetic heart diseases are common in younger people who have a cardiac arrest outside of the hospital and to see how this might affect their family members.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1725 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Pavia) |
| Trial ID | NCT06844851 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine the prevalence of hereditary heart diseases in patients who experience out-of-hospital cardiac arrest (OHCA) in the Lombardy Region, particularly focusing on individuals aged 50 and younger. Blood samples will be collected during resuscitation to analyze genetic variants that may contribute to cardiac diseases. The study will also assess the arrhythmic risk for family members of the patients and refine the classification of uncertain genetic variants. Data will be integrated with patient characteristics and environmental factors to enhance understanding of the causes of OHCA.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 50 years or younger who suffer from out-of-hospital cardiac arrest of medical etiology.
Not a fit: Patients under 18 years old or those with non-medical causes of cardiac arrest may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification and prevention of sudden cardiac deaths in young individuals through genetic insights.
How similar studies have performed: Other studies have shown success in identifying genetic causes of cardiac arrest, but this specific approach focusing on out-of-hospital cases is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All the patients suffering from OHCA of medical etiology in Lombardy Region ≤50 years, for whom resuscitation manoeuvres was started by EMS (AREU) Exclusion Criteria: * Patients under 18 years old * Patients with a non-medical cause of the cardiac arrest
Where this trial is running
Pavia, Pavia
- Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Pavia, Italy (Recruiting)
Study contacts
- Study coordinator: Enrico Baldi, MD
- Email: enrico.baldi@unipv.it
- Phone: +39 3293556062
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.