Evaluating dental health after enamel reduction in orthodontic patients using clear aligners

Evaluation of Dental and Periodontal Health After Interproximal Enamel Reduction, in Patients in Orthodontic Treatment With Clear Aligners, and Comparison Between Laser Diode and Sodium Fluoride for the Treatment of Dentin Hypersensitivity

Not applicable Interventional University of Campania Luigi Vanvitelli · NCT06685016

This study tests whether using a laser or fluoride can help reduce tooth sensitivity in orthodontic patients who are getting clear aligners and need some enamel removed.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment30 (estimated)
Ages17 Years to 100 Years
SexAll
SponsorUniversity of Campania Luigi Vanvitelli Academic / other
Locations1 site (Naples)
Trial IDNCT06685016 on ClinicalTrials.gov

What this trial studies

This study evaluates the dental and periodontal health of patients undergoing orthodontic treatment with clear aligners who require interproximal enamel reduction (IPR). It compares the effects of using a laser diode versus sodium fluoride on dentin hypersensitivity during treatment. The study aims to determine if these interventions can reduce the incidence of dentin hypersensitivity compared to a control group. The methodology involves assessing dental health outcomes and sensitivity levels using a Visual Analog Scale (VAS).

Who should consider this trial

Good fit: Ideal candidates are individuals in orthodontic treatment with clear aligners who require interproximal enamel reduction and have good oral and periodontal health.

Not a fit: Patients with enamel defects, cervical caries, periodontal disease, or a history of trauma or craniofacial anomalies may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved dental health outcomes and reduced sensitivity for patients undergoing orthodontic treatment with clear aligners.

How similar studies have performed: Other studies have shown promising results with similar approaches in managing dentin hypersensitivity during orthodontic treatments.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* to be in orthodontic treatment with clear aligners and this treatment requires interproximal enamel reduction;
* permanent dentition;
* good oral and periodontal health.

Exclusion Criteria:

* enamel defects;
* cervical caries;
* periodontal disease;
* history of trauma or craniofacial anomalies;
* pregnancy.

Where this trial is running

Naples

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Dentinal HypersensitivityPlaque, DentalBleeding GumClear AlignersInterproximal enamel reduction
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.