Clinical trial Recruiting at 1 site Phase 3 Interventional Ages 18 to 70

Which toothpaste works best for dentin sensitivity?

Official title: Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies on Instant and Short-term Relief of Dentin Hypersensitivity: a Randomized Clinical Trial

Run by Colgate Palmolive · NCT07664592 · Data updated 2026-11-12

This study tests three toothpaste types containing arginine or CSPS to see if they quickly relieve sensitivity in people with dentin hypersensitivity.

Quick facts

PhasePhase 3
Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment132 (estimated)
SponsorColgate Palmolive
Industry-sponsored
Locations1 site (Porto Alegre, Rio Grande do Sul)
StatusRecruiting
StartedJune 29, 2026
Main results expectedSeptember 2026
Study endsSeptember 2026
Registry record updatedAugust 7, 2026
Trial IDNCT07664592 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–70 with at least two exposed, sensitive teeth and generally good health who can commit to the 2-week study period.

Probably not a fit

Patients whose dentin hypersensitivity does not respond to the tested toothpaste formulations may not experience relief beyond baseline levels.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3, randomized, double-blind trial compares three dentin-occluding toothpastes: 8% arginine, 8% arginine with zinc phosphate, and 5% calcium sodium phosphosilicate. Participants have at least two sensitive teeth and undergo baseline sensitivity and quality-of-life assessments before being assigned to one toothpaste group. The study measures immediate relief in-office and short-term relief over 14 days using tactile and evaporative stimuli, with outcomes including sensitivity scales and the DHEQ-15. The trial is conducted at a single site with Colgate-Palmolive as lead sponsor and the Federal University of Rio Grande do Sul as collaborator.

Why it matters

Potential benefit: If successful, the study could identify a toothpaste that provides faster or greater relief from dentin hypersensitivity for people with sensitive teeth.

How similar studies have gone: Past studies have shown dentin-occluding toothpastes can reduce sensitivity, though comparative results across technologies vary and this study adds a direct head-to-head comparison.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Sign an Informed Consent Form;
2. Male or female 18 to 70 years of age, inclusive;
3. Be in good general health as determined by the study investigators (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve/hip replacements, etc);
4. Willingness to provide information related to their medical history;
5. Available for the two (2) weeks duration of the study;
6. Minimum of 16 uncrowned permanent natural teeth (excluding third molars and crowns);
7. Must present at least two (2) sensitive teeth which must meet ALL of the following criteria:

   1. Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion and/or gingival recession;
   2. Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale.

Exclusion Criteria:

1. Gross oral pathology, chronic disease, and/or history of allergies to any of the test products;
2. Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past month prior to start of the study;
3. Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months, dental cleaning it's permitted;
4. Sensitive teeth with a mobility greater than one;
5. Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures;
6. Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner; or other drugs that could affect pain sensation;
7. Current smokers and subjects with a history of alcohol or drug abuse;
8. Participation in any other oral clinical study for the duration of this study;
9. Self-reported pregnancy and/or currently breastfeeding;
10. Allergies to oral care products, personal care consumer products, and/or their ingredients;
11. Medical condition which prohibits not eating/drinking for 4 hours.
12. Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study;
13. Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine);
14. Current use of orthodontic appliances (including fixed braces, clear aligners, or permanent retainers)

Where it's running

  • Ieapom
    Porto Alegre, Rio Grande do Sul, Brazil
    Recruiting

Study contacts

  • Principal investigator: Cassiano K Rosing, PhD — Federal University of Rio Grande do Sul
  • Study coordinator: Cassiano K Rosing, PhD
  • Email: ckrosing@hotmail.com
  • Phone: 5551995119123

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.