Which toothpaste works best for dentin sensitivity?
Official title: Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies on Instant and Short-term Relief of Dentin Hypersensitivity: a Randomized Clinical Trial
Run by Colgate Palmolive · NCT07664592 · Data updated 2026-11-12
This study tests three toothpaste types containing arginine or CSPS to see if they quickly relieve sensitivity in people with dentin hypersensitivity.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 132 (estimated) |
| Sponsor | Colgate Palmolive Industry-sponsored |
| Locations | 1 site (Porto Alegre, Rio Grande do Sul) |
| Status | Recruiting |
| Started | June 29, 2026 |
| Main results expected | September 2026 |
| Study ends | September 2026 |
| Registry record updated | August 7, 2026 |
| Trial ID | NCT07664592 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–70 with at least two exposed, sensitive teeth and generally good health who can commit to the 2-week study period.
✕Probably not a fit
Patients whose dentin hypersensitivity does not respond to the tested toothpaste formulations may not experience relief beyond baseline levels.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 3, randomized, double-blind trial compares three dentin-occluding toothpastes: 8% arginine, 8% arginine with zinc phosphate, and 5% calcium sodium phosphosilicate. Participants have at least two sensitive teeth and undergo baseline sensitivity and quality-of-life assessments before being assigned to one toothpaste group. The study measures immediate relief in-office and short-term relief over 14 days using tactile and evaporative stimuli, with outcomes including sensitivity scales and the DHEQ-15. The trial is conducted at a single site with Colgate-Palmolive as lead sponsor and the Federal University of Rio Grande do Sul as collaborator.
Why it matters
Potential benefit: If successful, the study could identify a toothpaste that provides faster or greater relief from dentin hypersensitivity for people with sensitive teeth.
How similar studies have gone: Past studies have shown dentin-occluding toothpastes can reduce sensitivity, though comparative results across technologies vary and this study adds a direct head-to-head comparison.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Sign an Informed Consent Form; 2. Male or female 18 to 70 years of age, inclusive; 3. Be in good general health as determined by the study investigators (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve/hip replacements, etc); 4. Willingness to provide information related to their medical history; 5. Available for the two (2) weeks duration of the study; 6. Minimum of 16 uncrowned permanent natural teeth (excluding third molars and crowns); 7. Must present at least two (2) sensitive teeth which must meet ALL of the following criteria: 1. Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion and/or gingival recession; 2. Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale. Exclusion Criteria: 1. Gross oral pathology, chronic disease, and/or history of allergies to any of the test products; 2. Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past month prior to start of the study; 3. Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months, dental cleaning it's permitted; 4. Sensitive teeth with a mobility greater than one; 5. Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures; 6. Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner; or other drugs that could affect pain sensation; 7. Current smokers and subjects with a history of alcohol or drug abuse; 8. Participation in any other oral clinical study for the duration of this study; 9. Self-reported pregnancy and/or currently breastfeeding; 10. Allergies to oral care products, personal care consumer products, and/or their ingredients; 11. Medical condition which prohibits not eating/drinking for 4 hours. 12. Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study; 13. Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine); 14. Current use of orthodontic appliances (including fixed braces, clear aligners, or permanent retainers)
Where it's running
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Ieapom
Porto Alegre, Rio Grande do Sul, Brazil Recruiting
Study contacts
- Principal investigator: Cassiano K Rosing, PhD — Federal University of Rio Grande do Sul
- Study coordinator: Cassiano K Rosing, PhD
- Email: ckrosing@hotmail.com
- Phone: 5551995119123
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Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.