Endometriosis: See if Algologic Care Before Surgery Helps with Pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study explores a preoperative pathway of algologic care for women with endometriosis-related pain who are planning surgery. Eligible participants have radiologically confirmed endometriosis, impaired quality of life due to pain, and a surgical plan for lesion resection. The goal is to determine if addressing pain mechanisms such as neuropathic features before surgery can improve outcomes or reduce postoperative pain. The trial compares the care pathway timing to standard pre-surgical management within a structured enrollment window. Randomization is limited by a maximum 4-month interval between randomization and scheduled surgery.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Maternal age from 18 up to 50 years old (50 non included).
* Women affiliated to social coverage insurance
* Women who understand French
* Women who signed the written consent
* Women with impaired quality of life (pain) linked to endometriosis
* Women with formal radiological signs of endometriosis (MRI lesions more than 5 mm or endometrioma more than 20 mm on radiological examinations).
* Surgical indication for resection of lesions by laparoscopy or robotic surgery for management of pain or impairment of quality of life
* Patients requiring complete conservative or radical resections of all lesions
* Indication of surgery validated within dedicated meeting for endometriosis.
* Purpose of pain associated or not with infertility
* Date of surgery fixed with sufficient time for algological treatment. Maximum delay of 4 months between randomization and surgery

Exclusion criteria:

* Women undergoing surgery for the purpose of infertility
* Patient with previous surgery for removal of deep lesions of endometriosis or endometriotic cysts (history of exploratory laparoscopy accepted)
* Patient with suspicious lesions on MRI or specialized ultrasound.
* A patient who needs to be treated for another uterine pathology at the same time.
* Pregnant women
* Patient with a desire for pregnancy immediately and/or within one year after surgery
* Women who refuse clinical examination (some algological tests couldn't be performed without clinical examination)
* Patient who has already received algological treatment or who should receive it before surgery
* Patient with previous other psychiatric disorders (depressive symptoms treated)
* Women without rights

Where it's running

• Limoges University hospital
  Limoges, France, France Recruiting
• Bordeaux University Hospital
  Bordeaux, France, France Not yet recruiting
• Ifemendo
  Bordeaux, France, France Not yet recruiting
• Versailles Hospital
  Le Chesnay, France, France Not yet recruiting
• Saint-Vincent-de-Paul Hospital
  Lille, France, France Not yet recruiting
• Poissy-St-Germain Intercommunal hospital center
  Poissy, France, France Not yet recruiting

Study contacts

• Principal investigator: François Dr. Margueritte — University Hospital, Limoges
• Study coordinator: Safirah AKOWANOU
• Email: safirah.akowanou@chu-limoges.fr
• Phone: +33555058755

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating physical therapy for endometriosis pain management

  This study is testing if a mix of education about pain and specific exercises can help women with endometriosis feel less pain and improve their quality of life.

  Recruiting University of Seville · Seville · NCT06795243

• Using integron tests to guide first-line antibiotics for non-severe UTI in adults

  This trial tests whether detecting integrons in urine can help doctors choose appropriate antibiotics for adults with non-severe urinary tract infections who had a resistant gram-negative infection in the past.

  Recruiting University Hospital, Limoges · Chambray-lès-Tours and 6 other locations · NCT07675018

• B Lymphocyte Populations in the Lungs of ICU Patients on Ventilation

  This study tests the presence and roles of B lymphocytes in the lungs of adults on invasive ventilation, to see how humoral immunity relates to ventilator-associated pneumonia.

  Recruiting University Hospital, Limoges · Limoges · NCT07436780

• Diffusion in the growing spine: ADC of the intervertebral disc in children

  This study tests whether MRI diffusion measurements in the intervertebral disc can help understand differences between scoliotic and healthy children.

  Recruiting University Hospital, Limoges · Limoges and 1 other locations · NCT07331298

• Identifying harmful IgA in IgA-related kidney disease

  This project will test whether specific forms of IgA in adults with IgA nephropathy or IgA vasculitis cause kidney damage by analyzing blood and biopsy samples.

  Recruiting University Hospital, Limoges · Limoges · NCT07295808

• Esmolol versus sufentanil for smoother recovery after outpatient laparoscopic gallbladder removal

  This study will test whether replacing sufentanil with esmolol during general anaesthesia helps adults having outpatient laparoscopic gallbladder removal recover with fewer opioid-related side effects.

  Recruiting at 2 sites Phase 4 University Hospital, Limoges · Brive-la-Gaillarde, France and 1 other locations · NCT07019818

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.