Esmolol versus sufentanil for smoother recovery after outpatient laparoscopic gallbladder removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicentre equivalence trial enrolling 120 adults scheduled for outpatient laparoscopic cholecystectomy under general anaesthesia with orotracheal intubation. Participants are randomized to receive either esmolol or sufentanil as the intraoperative agent, and each patient is followed for two days with a phone call the day after surgery to complete a quality-of-recovery questionnaire and report pain medication use. Key exclusions include current beta-blocker use, contraindications to beta-blockers, uncontrolled hypertension, severe obesity, pregnancy, and planned difficult intubation. The primary objective is to compare recovery quality and postoperative opioid-related effects between the two groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients
* ASA I to III
* Scheduled outpatient cholecystectomy
* General anesthesia with orotracheal intubation
* Patient with signed consent
* Patient affiliated to a social security scheme

Exclusion Criteria:

* Patients on beta-blockers
* Uncontrolled hypertension
* Contraindication to beta-blockers
* Hypersensitivity to the active substance or to one of the excipients of sufentanil and esmolol
* Pre-existing hemodynamic abnormality
* Intubation planned to be difficult during the anaesthesia consultation
* Severe obesity (BMI \> 35 kg/m2)
* Pregnant or breast-feeding women
* Patients deprived of liberty
* Patients under guardianship

Where it's running

• CH Brive
  Brive-la-Gaillarde, France, France Recruiting
• CHU Limoges
  Limoges, France, France Recruiting

Study contacts

• Study coordinator: Romain NIEUVIARTS, Physician
• Email: romain.nieuviarts@ch-brive.fr
• Phone: +33555926186

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing pain relief from local anesthetic given inside the abdomen versus under the skin after laparoscopic gallbladder removal

  This trial will try two ways of giving a local anesthetic—inside the abdomen or under the skin—to see which reduces pain after laparoscopic gallbladder removal.

  Recruiting Phase 4 Rawalpindi Medical College · Rawalpindi, Punjab Province · NCT07409688

• Fluorescent bile duct imaging with standard versus reduced indocyanine green doses during laparoscopic gallbladder removal

  This will see if a much lower dose of indocyanine green given shortly before laparoscopic gallbladder removal shows the bile ducts as well as the standard higher dose given hours earlier.

  Recruiting Phase 4 Instituto de Investigación Biomédica de Salamanca · Salamanca, Salamanca and 1 other locations · NCT07195331

• Subcostal TAP Block and EEG Changes During Laparoscopic Gallbladder Surgery

  This observational study tests whether adding a subcostal TAP block to standard IV opioid therapy affects intraoperative brain activity measures and pain needs in adults undergoing laparoscopic cholecystectomy.

  Recruiting Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Istanbul · NCT07818954

• Dexmedetomidine vs magnesium as intraperitoneal add-ons to bupivacaine for laparoscopic gallbladder removal

  This study tests whether adding dexmedetomidine or magnesium sulfate to bupivacaine injected inside the abdomen provides better pain relief after laparoscopic cholecystectomy for adults without serious health issues.

  Recruiting Alexandria University · Alexandria · NCT07693621

• How different ventilator settings affect lung energy during gallbladder surgery

  This study tests whether two ventilator modes (VCV and PRVC) deliver different amounts of energy to the lungs in adults undergoing laparoscopic gallbladder removal.

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Yenimahalle, Ankara · NCT07670494

• Erector Spinae Plane Block with Low-Flow Anaesthesia in Laparoscopic Cholecystectomy

  This trial tests whether a nerve block done before surgery plus very low-flow anesthesia reduces pain and opioid use after gallbladder removal.

  Recruiting Taksim Egitim ve Arastirma Hastanesi · Istanbul · NCT07653490

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.