Closed Surgical Technique vs Modified Papilla Preservation Technique in treating interdental periodontal defects

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares two surgical approaches for treating isolated interdental periodontal defects: a closed surgical technique (CST) and a modified papilla preservation technique (MPPT), both with injectable platelet-rich fibrin (i-PRF). Participants have residual pockets with deep probing depths and signs of inflammation after non-surgical treatment. Outcomes include clinical attachment level gain, radiographic bone fill, and biomarker changes (VEGF, OPG, RANKL) over 12 months. Blood is drawn to prepare i-PRF, and standardized measurements are taken at baseline and follow-up visits. The study follows a structured visit schedule with initial screening, baseline surgery, and subsequent assessments to compare efficacy and safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Systematically healthy subjects, not having consumed antibiotics 3 months before surgical periodontal treatment (baseline)
* Smokers \<10 cig/day, former smokers or no smokers
* Periodontal patients fulfilling non-surgical initial periodontal treatment at least 3 months before surgical periodontal treatment (baseline day) and presenting at least one residual pocket with PPD and CAL ≥6mm and bleeding on probing, located interproximally with intrerdental site ≥2mm.
* Compliant patients presenting high standards of oral hygiene (full mouth Plaque Index \<20%) strictly susceptible in Supportive Periodontal

Exclusion Criteria:

* Untreated active periodontal inflammation
* Poorly controlled systematic diseases
* Disorders compromise wound healing
* Bisphosphonate medications
* Patients under radiotherapy or chemotherapy
* Drug-induced gingival hyperplasia
* Pregnancy or lactation
* Poor compliance during steps 1 and 2 of cause-related periodontal treatment
* Compromised oral hygiene (full mouth Plaque Index \>30%),
* circumferential bone defect or narrow intrerdental site ≤2mm.

Where it's running

• Dental School, Aristotle University, Dept of Preventive Dentistry, Periodontology and Implant Biology
  Thessaloniki, Greece, Greece Recruiting

Study contacts

• Study coordinator: Danae Apatzidou, Professor
• Email: perioapatzidou@yahoo.gr
• Phone: +30 6934770361

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.