Dexamethasone and Spinal Block Duration in Lower Abdominal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a phase 4, interventional study comparing intravenous dexamethasone to placebo in adults undergoing lower abdominal surgery with spinal anesthesia. Participants with ASA I-II are randomized to receive 8 mg dexamethasone in saline or saline alone before spinal anesthesia with hyperbaric bupivacaine. A standard spinal technique using a 25-gauge needle and 12–15 mg of 0.75% hyperbaric bupivacaine will be used, and blocks will be monitored with sensory and motor assessments to determine duration. Blinding of personnel assessing block duration is maintained. The trial aims to determine if systemic dexamethasone extends the duration of neuraxial anesthesia for improved perioperative management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing lower abdominal surgeries and orthopaedic surgeries including pelvic and lower extremity surgeries
* Patients classified as American Society of Anesthesiologists (ASA) physical status I or II

Exclusion Criteria:

* Patients with a history of spinal surgery, spinal instrumentation, or previous failed spinal anaesthesia
* Patients with pre-existing neurological disorders, peripheral neuropathy, or sensory/motor deficits
* Patients with known hypersensitivity or allergy to local anaesthetic agents or dexamethasone
* Patients with congenital spinal deformities or acquired spinal conditions such as advanced spondylosis or kyphoscoliosis that may interfere with neuraxial block
* Patients with contraindications to spinal anaesthesia, including coagulopathy, local infection at the injection site, or raised intracranial pressure
* Patients with diabetes mellitus, chronic steroid therapy, immunosuppression, or systemic infection (due to steroid use)
* Pregnant patients or those undergoing emergency surgeries

Where it's running

• Holy Family Hospital
  Rawalpindi, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Tayyab Principal Investigator, MBBS
• Email: tayyabmasood428@gmail.com
• Phone: +92 308 5220273

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.