Developing a viability index for machine-perfused livers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve the transplantability of discarded liver grafts using machine perfusion technology. By collecting biopsies from livers before and after transplantation, researchers will analyze metabolite and gene expression data to establish a viability index. This index will help determine which machine-perfused livers can be successfully transplanted, potentially increasing the availability of donor organs. The study focuses on patients who are candidates for deceased-donor liver allografts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female 18-75 years of age.
* Candidate for a deceased-donor liver allograft.

Exclusion Criteria:

* Seropositivity for HIV-1.

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Heidi Yeh, MD — Massachusetts General Hospital
• Study coordinator: Heidi Yeh, MD
• Email: hyeh@mgh.harvard.edu
• Phone: 617-726-3664

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• MRI versus ultrasound for early liver cancer detection, body composition, and decompensation risk in cirrhosis

  This project will test whether abbreviated MRI or ultrasound is better at finding early liver cancer and measuring muscle and fat in adults with cirrhosis.

  Recruiting Linkoeping University · Linköping, Select A State Or Province · NCT07291141

• Using TIPS before sleeve gastrectomy to improve outcomes for people with cirrhosis and severe obesity

  This trial tests whether placing a TIPS (a portal decompression procedure) before sleeve gastrectomy helps adults with cirrhosis, clinically significant portal hypertension, and severe obesity lose weight, feel better, and have fewer complications.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT07058155

• Evaluating eye characteristics to improve liver transplant outcomes

  This study is testing whether eye features can help doctors better understand and improve health outcomes for people with chronic liver disease before and after they get a liver transplant.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT06756009

• How chronic liver diseases connect with other long-term illnesses

  We will look back at hospital records to see if chronic liver diseases are linked with other systemic illnesses in adults who visited Tzu Chi gastroenterology clinics.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City · NCT04525833

• Using antibiotics to prevent infections in patients with gastric varices undergoing treatment

  This study is testing if giving antibiotics to patients with liver disease and gastric varices during treatment can help prevent infections and reduce the chances of bleeding again.

  Recruiting Phase 4 Taipei Veterans General Hospital, Taiwan · Taipei · NCT04140578

• Analyzing non-invasive methods for liver lesions in cirrhosis patients

  This study is testing new non-invasive imaging methods to see if they can accurately identify liver lesions in patients with cirrhosis and predict their treatment outcomes and survival.

  Recruiting University Hospital, Bonn · Bonn · NCT03746210

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.