Dentin Graft Options for Socket Preservation after Wisdom Tooth Removal
Official title: The Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation After Surgical Extraction of Impacted Mandibular Third Molar
Run by Horus University · NCT06457373 · Data updated 2026-11-12
This study tests whether Demineralized Dentin Allograft works as well as Demineralized Dentin Autograft to protect the jawbone after removing an impacted lower wisdom tooth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 35 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Horus University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Damietta, New-Damietta) |
| Status | Recruiting |
| Started | August 13, 2026 |
| Main results expected | August 1, 2027 |
| Study ends | August 30, 2027 |
| Registry record updated | August 18, 2026 |
| Trial ID | NCT06457373 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are 25–35 years old, ASA I, non-smokers/non-alcohol users, with bilaterally impacted mandibular third molars of similar difficulty, and socket conditions meeting study criteria.
✕Probably not a fit
Patients with pregnancy, systemic disease, prior chemotherapy/radiotherapy, or conditions outside the inclusion criteria may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants are adults aged 25–35 with bilaterally impacted lower wisdom teeth undergoing extraction. The trial compares two graft types—demineralized dentin allograft from a donor and demineralized dentin autograft from the patient’s own tissue—to see which better preserves alveolar ridge dimensions, using clinical and radiographic assessments. It is conducted at Horus University in Egypt, enrolling adults with good health status and no pre-existing oral pathology in the extraction sockets. Outcome measures include socket preservation over time and radiographic changes. The study excludes pregnant or lactating individuals and those with certain systemic conditions or prior cancer treatments.
Why it matters
Potential benefit: If successful, the approach could improve bone preservation after tooth extraction, potentially aiding future dental procedures.
How similar studies have gone: Previous work in dentin grafting has shown potential for bone preservation, but direct head-to-head comparisons of allograft versus autograft in this context are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients aged between 25 to 35 years old. 2. Patients scored as (ASA I). 3. No adverse habits such as smoking, tobacco chewing, alcohol. 4. Patients having bilaterally impacted mandibular third molar with similar degree of difficulty according to (Kim JY, et al). 5. The recipient alveolar sockets are free of any pre-existing periapical pathology, based on x-ray. 6. Alveolar sockets with a depth of 5 mm or more, using periodontal probe for assessment. 7. Patients sign a consent for all procedures. Exclusion Criteria: * 1\) Pregnant or lactating patients. 2) Relevant systemic diseases. 3) Patients with history of chemotherapy or radiotherapy.
Where it's running
-
Faculty of Dentistry- Horus University in Egypt
Damietta, New-Damietta, Egypt Recruiting
Study contacts
- Principal investigator: Mohamed Habib, B.D.S — Faculty of Dentistry- Horus University in Egypt
- Study coordinator: Mohamed Habib, B.D.S
- Email: mbasiouny@horus.edu.eg
- Phone: +2001069505336
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.