Comparing two methods of nerve blocks for lung surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of two different ultrasound-guided paravertebral nerve block techniques during the induction phase of thoracoscopic lung lobectomy. Participants will be randomly assigned to receive either a superficial or deep paravertebral block to assess which method better maintains hemodynamic stability. The study aims to enroll 168 patients across five hospitals, focusing on optimizing pain management and recovery outcomes. By comparing these techniques, the trial seeks to enhance postoperative comfort and reduce the need for general anesthesia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients scheduled for elective two-port video-assisted thoracoscopic lobectomy
* Age: ≥18 years
* ASA classification: I-III
* BMI: 18-30 kg/m²

Exclusion Criteria:

* Severe hypertension (SBP ≥180 mmHg or DBP ≥110 mmHg)
* MAP \<70 mmHg before anesthesia induction
* Emergency surgery
* Severe cardiovascular disease, including history of cerebral or thoracic/abdominal aortic aneurysm
* Congestive heart failure (New York Heart Association class III or IV)
* Untreated or unstable ischemic heart disease
* Severe aortic or mitral valve disease
* Pregnancy or lactation
* Coagulation disorders
* Bacteremia, sepsis, or infection at the puncture site
* Allergy to study-related drugs
* Severe liver and kidney dysfunction
* Neurological disorders, spinal disease (deformity or trauma), history of spinal surgery, or abnormal skin sensation in the thoracic or back region
* Existing or anticipated difficult airway management
* Other conditions deemed unsuitable for inclusion by the investigators Forty patients who required CT (3D) imaging technology to observe drug diffusion after the implementation of the two methods were included as follows: patients who were scheduled to undergo double-hole thoracoscopic lobectomy, aged ≥18 years, ASA grade I to III, BMI 18 to 30kg/m2, and required preoperative CT localization. Exclusion criteria In addition to the above conditions, patients with a history of anaphylaxis induced by contrast agents should be excluded.

Where it's running

• Nanjing First Hospital
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Yajie Xu
• Email: xuyajiechina@163.com
• Phone: 86 18651815258

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.