5 vs 10 mcg norepinephrine bolus for postinduction hypotension in emergency abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two fixed doses of norepinephrine used as a bolus to correct postinduction hypotension during emergency abdominal surgery. After a stroke volume guided fluid assessment, patients receive either 5 mcg or 10 mcg norepinephrine, with hemodynamics monitored every 2 minutes for 30 minutes after skin incision. The protocol includes repeated passive leg raising and fluid challenges based on stroke volume response to optimize perfusion while minimizing fluid overload. Eligible adults are ASA I–III undergoing emergency abdominal surgery, excluding those with significant cardiac disease, ongoing vasopressor therapy, pregnancy, or drug allergies. Cairo University leads the trial with no listed collaborators and site-specific execution in Cairo.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients, American Society of anesthesiologists (ASA) I-III undergoing emergency abdominal surgery

Exclusion Criteria:

* Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions)
* Patients on vasopressor infusion,
* Pregnant or lactating women,
* Allergy of any of the study drugs

Where it's running

• Cairo University
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Maha Mostafa, MD
• Email: maha.mostafa@cu.edu.eg
• Phone: +201000365115

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• EASIX and Post-Induction Hypotension in Frail Adults Undergoing Non-Cardiac Surgery

  This study tests whether the EASIX score, calculated from routine labs, can predict post-induction low blood pressure in frail adults having elective non-cardiac surgery under general anesthesia.

  Recruiting Konya City Hospital · Konya · NCT07642765

• Can neck vein ultrasound predict low blood pressure and kidney injury during abdominal surgery?

  This observational study tests whether ultrasound measurements of the internal jugular vein can help predict low blood pressure during anesthesia induction and possible kidney injury after abdominal surgery.

  Recruiting Tîrgu Mureș Emergency Clinical County Hospital, Romania · Târgu Mureş, Mureș County · NCT07638306

• IV paracetamol and blood pressure in adults having emergency laparotomy

  This trial will test whether a single dose of IV paracetamol causes drops in blood pressure in adults undergoing emergency laparotomy.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07466108

• Outcomes of VV-ECMO during emergency thoracic surgery

  This project tries to compare outcomes for adults who receive veno-venous ECMO during or after emergency chest surgery with patients who receive VV-ECMO for medical respiratory failure.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07016685

• Femoral versus radial arterial pressure monitoring during cardiac surgery

  This trial tests whether femoral arterial catheters give more accurate continuous blood pressure readings than radial catheters in adults undergoing cardiac surgery with cardiopulmonary bypass.

  Recruiting at 2 sites Centre Hospitalier Universitaire de Besancon · Besançon and 1 other locations · NCT06952907

• Effects of hemoglobin levels on kidney injury after emergency surgery

  This study is testing if having higher hemoglobin levels before emergency surgery can help prevent kidney injury in patients after the operation.

  Recruiting Samsun University · Samsun · NCT06857630

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.