EASIX and Post-Induction Hypotension in Frail Adults Undergoing Non-Cardiac Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational cohort looks at whether the preoperative EASIX score is associated with post-induction hypotension (PIH) within 15 minutes after anesthesia induction in frail adults. 160 patients with Clinical Frailty Scale of 4 or higher will be enrolled, and mean arterial pressure will be recorded every 2 minutes during the first 15 minutes post-induction. EASIX is computed from LDH, creatinine, and platelet count obtained within 24 hours before surgery. A standardized induction protocol is used, with ongoing monitoring and documented outcomes including PIH and the performance of EASIX as a diagnostic test. Multivariable analysis will adjust for age, sex, ASA class, baseline MAP, antihypertensive use, fasting duration, and induction doses to explore independent associations and potential interactions with frailty level.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Scheduled for elective non-cardiac surgery under general anesthesia
* Clinical Frailty Scale (CFS) score of 4 or above
* Available routine preoperative laboratory values (LDH, creatinine, platelet count) within 24 hours before surgery

Exclusion Criteria:

* Cardiac surgery
* Emergency surgery
* Preoperative vasopressor infusion
* Severe hematological disease
* Missing laboratory data required for EASIX calculation

Where it's running

• Konya City Hospital
  Konya, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Mustafa Aydemir, MD — Konya City Hospital
• Study coordinator: Mustafa Aydemir, MD
• Email: drmustafaaydemir02@gmail.com
• Phone: +903323105000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Postprandial drop and frailty in older adults having planned noncardiac surgery

  This study tests whether a drop in blood pressure after meals and frailty predict low blood pressure after anesthesia starts in adults 65 and older undergoing planned noncardiac surgery.

  Recruiting Konya City Hospital · Konya, Konya · NCT07914920

• Frailty Training for Emergency Nurses in Morocco

  This trial tests whether a four-module training program helps Moroccan emergency nurses recognize and care for frail older adults in the ER.

  Recruiting Cadi Ayyad University · Safi, SAFI · NCT07892612

• Temperature management during long abdominal surgeries

  This study tests whether warming intravenous fluids to 39 °C, in addition to standard warm air warming, helps keep patients warmer during long abdominal operations compared with using room-temperature fluids.

  Recruiting The Leningrad Regional Clinical Hospital · Saint Petersburg · NCT07854704

• Physical Function and Fall Risk in Older Adults in Lalín's Frailty Prevention Program

  This study will look at how physical function and fall risk change in people 70 and older who participate in a routine frailty and falls prevention program, by comparing assessments before and after the 8–12 week program.

  Recruiting University of Vigo · Lalín, Pontevedra · NCT07848802

• Home-based multicomponent exercise program for older adults with osteosarcopenia and frailty

  This study tests a home-based exercise program built on the Fogg Behavior Model to see if it improves frailty, muscle strength, physical function, bone density, and quality of life in adults aged 60–85 with osteosarcopenia and frailty.

  Recruiting at 2 sites Affiliated 2 Hospital of Nantong University · Nantong, Jiangsu and 1 other locations · NCT07845656

• VIVI-OLIVE: Multicomponent Exercise and Olive Oil for Older Adults at High Risk of Falls

  In adults 75 and older at high risk of falling, this study tests whether a 24-month plan of personalized exercise, Mediterranean diet guidance, and 60 mL of extra virgin olive oil daily can improve walking speed and reduce fall risk.

  Recruiting Fundacion Miguel Servet · Pamplona, Navarre · NCT07829484

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.