Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Costotransverse foramen block versus thoracic paravertebral block for pain control after lung cancer thoracotomy

Official title: Costotransverse Foramen Block Versus Thoracic Paravertebral Block in Thoracotomy for Lung Cancer: A Randomized Controlled Trial

Run by National Cancer Institute, Egypt · NCT07367581 · Data updated 2026-11-12

This will test whether the costotransverse foramen block or the thoracic paravertebral block gives better pain relief for adults having thoracotomy for lung cancer.

More Lung Cancer trials

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment70 (estimated)
SponsorNational Cancer Institute, Egypt
Academic / other
Locations1 site (Cairo)
StatusRecruiting
StartedJanuary 24, 2026
Main results expectedJune 1, 2026
Study endsJune 1, 2026
Registry record updatedJanuary 27, 2026
Trial IDNCT07367581 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18–65 years old with ASA physical status II–III, BMI 18–35 kg/m2, and scheduled for thoracotomy for lung cancer who can consent are the ideal candidates.

Probably not a fit

Patients with contraindications to regional anesthesia, severe organ failure, morbid obesity, chronic pain therapy, or inability to cooperate are unlikely to gain benefit from this comparison.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Thoracotomy causes severe postoperative pain and reliable pain control is a major clinical challenge. This study compares a newer nerve block technique, the costotransverse foramen block (CTFB), with the established thoracic paravertebral block (TPVB) in patients undergoing thoracotomy for lung cancer. Eligible patients will receive either CTFB or TPVB as part of their perioperative analgesia and investigators will track postoperative pain scores, opioid consumption, and complications. The aim is to see if CTFB can match or improve pain control while reducing side effects and opioid use.

Why it matters

Potential benefit: If successful, CTFB could provide comparable or better pain relief with fewer side effects and lower opioid needs, improving recovery after thoracotomy.

How similar studies have gone: CTFB is a recently described technique with mainly cadaver and case report data so far, whereas TPVB and other regional blocks have established evidence for thoracotomy pain control.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age \> 18 years and ≤ 65 years old.
* American Society of Anesthesiologists (ASA) physical status II-III.
* Body mass index 18-35 kg/m2.
* Patients scheduled for thoracotomies for lung cancer.

Exclusion Criteria:

* Patient refusal.
* History of sensitivity to local anesthetics.
* History of psychological disorders.
* Contraindication to regional anesthesia, e.g., local sepsis, pre-existing peripheral neuropathies, and coagulopathy.
* Severe respiratory, cardiac, hepatic, or renal disease.
* Morbid obesity.
* Uncooperative patients.
* Patients on chronic pain therapy.

Where it's running

  • Cairo University
    Cairo, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.