Comparing different methods for cleaning root canals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness and safety of various root canal cleaning devices, including an inertial cavitation device, passive ultrasonic irrigation, and conventional methods. It involves a prospective, randomized, non-blinded design with three arms, focusing on patients aged 18 to 75 years who require root canal treatment due to apical periodontitis. Participants will record their post-operative pain levels and follow-up visits will include intraoral X-rays to assess healing rates. The study will analyze clinical outcomes over a 12 to 24-month period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

•Patients aged between 18-75 years with ASA (American Society of Anesthesiologists) classification 1 and 2.

ASA 1: A normal healthy patient. Example: Fit, non-obese BMI (Body mass index) under 30, a non-smoking patient with good exercise tolerance.

ASA 2: A patient with mild systemic disease. Example: Patient with no functional limitations and a well-controlled disease (e.g., treated hypertension, obesity with BMI under 35, frequent social drinker, or cigarette smoker).

* Patients who agreed to participate and who have signed the informed consent.
* Patients presenting with symptomatic and/or asymptomatic apical periodontitis and radiographic evidence of apical periodontitis in anterior or posterior teeth larger than 1.5 mm in diameter.
* Mature tooth with closed apices
* Tooth that has never been treated with root canal therapy.

Exclusion Criteria:

* Patients, who have pre-existing health or oral conditions that placed them at risk during the trial.
* Patients with generalized untreated periodontal disease.
* Patients with a history of analgesic intake within the past 3 days or antibiotics in the last 1 month.
* Uncooperative patients
* Teeth with immature apices, root resorption, or requiring extensive prosthetic rehabilitation.
* Teeth that cannot be made functional nor restored or difficult to access teeth with no importance (wisdom teeth)
* Teeth with insufficient periodontal support
* Teeth with poor prognosis, for example due to deep root caries, large root resorption or open apex cases
* Fractured teeth
* Local anatomical factors such as an inaccessible root end.
* Presence of fractured instrument in the root canal
* Pregnant women
* Patients unable to understand the study procedure.

Where it's running

• İstanbul Medipol Universitesi, Faculty of Dentistry, Department of Endodontics
  Istanbul, Unkapanı, Fatih, Turkey Recruiting

Study contacts

• Study coordinator: Tan Fırat Eyüboglu Assoc. Prof.
• Email: tfeyuboglu@yahoo.com
• Phone: +90 530 463 60 59

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Activation techniques in antimicrobial photodynamic therapy for retreatment of apical periodontitis

  This trial tests whether different methods of agitating methylene blue during antimicrobial photodynamic therapy can improve healing and reduce infection in teeth that prior root canals had treated for asymptomatic apical periodontitis.

  Recruiting Karadeniz Technical University · Trabzon, Ortahisar · NCT07921277

• Conventional and nano-metronidazole irrigation with or without ultrasonic activation for necrotic single-rooted teeth with apical periodontitis

  This study tests whether conventional metronidazole or a nano-formulated version, used as root canal irrigants with or without ultrasonic activation, can reduce post-operative pain and endotoxin levels in necrotic single-rooted teeth with apical periodontitis.

  Recruiting October 6 University · Giza, Giza Governorate · NCT07897591

• Post-operative Pain and Healing After Root Canal Re-Treatment Using Laser-Activated Irrigation vs Sonic or No Activation

  This study tests whether laser-activated irrigation or sonic activation helps reduce post-operative pain and improve healing after re-treating a tooth with persistent apical inflammation, compared to conventional needle irrigation.

  Recruiting at 2 sites University Ghent · Antwerp and 1 other locations · NCT07883486

• Different endodontic motor motions during root canals and their effect on pain

  This study tests whether using different apical motion modes on endodontic motors during root canal work changes postoperative pain in adults with chronic apical periodontitis.

  Recruiting Alanya Alaaddin Keykubat University · Antalya · NCT07714733

• Two irrigation methods and activation techniques during a single-visit retreatment: does pain differ after root canal retreatment?

  This study tests whether two different irrigation approaches and activation methods change postoperative pain after a single-visit retreatment in adults with a prior root canal.

  Recruiting Phase 4 TC Erciyes University · Kayseri · NCT07599254

• i-PRF regenerative treatment versus conventional non-surgical root canal retreatment for failed front teeth

  This trial will see if adding injectable platelet-rich fibrin (i-PRF) to regenerative treatment helps adults 18–50 with failed root canals and periapical lesions heal better than standard non-surgical retreatment.

  Recruiting Marmara University · Istanbul · NCT07448571

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.