Blood-based tests and digital cognitive checks to help triage dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The SANDBOX study looks at integrating blood measurements, APOE genotyping, and digital cognitive assessments into Memory Clinic workflows to speed up dementia triage. Adults aged 50+ referred to a Memory Clinic may participate, with results shared with clinicians to inform diagnosis while preserving standard care. Participants provide blood samples, a dried blood spot, and complete a digital cognitive test battery plus a recorded language task; results are used to support clinical decisions and are withheld until a memory appointment to avoid bias. A follow-up at 12 months includes repeat testing and assessments of psychological impact and cost-effectiveness, with exploratory AI analyses exploring biomarker relationships. Genetic counseling is offered for APOE4 status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The participant is willing and able to provide informed consent for participation in the study, or if unable to consent, a consultee (nearest of kin or holder of Power of Attorney) is available to make a declaration.
* Eligibility for recruitment in Scotland is restricted to participants who are able to provide informed consent themselves; participants requiring consultee consent will not be recruited in Scotland.
* Male or female, aged 50 years or older.
* The participant is currently on a waiting list for a participating Memory Clinic.
* The participant lives within traveling distance to a study site.
* The participant agrees to complete all study procedures, including genetic testing.

Exclusion Criteria:

* The participant may not enter the study if any of the following criteria apply:
* The participant has known or anticipated challenges with venous blood sampling.
* The participant is not fluent in English.
* The participant has a historical diagnosis of dementia.

Where it's running

• Imperial College Healthcare NHS Trust
  London, Greater London, United Kingdom Recruiting
• Central and North West London NHS Foundation Trust
  London, London, United Kingdom Recruiting
• West London NHS Trust
  London, London, United Kingdom Recruiting
• Surrey and Borders Partnership NHS Foundation Trust
  London, Surrey, United Kingdom Recruiting
• Aneurin Bevan University Health Board Clinical Research Centre
  Newport, Wales, United Kingdom Recruiting
• Bradford District Care Foundation Trust
  Bradford, United Kingdom Recruiting

Study contacts

• Study coordinator: Victoria B Medina, MRes
• Email: victoria@primamente.com
• Phone: +447493339995

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Blood tests using plasma biomarkers to diagnose and track Alzheimer’s disease

  A large, year-long study in Milan is testing whether blood markers can help diagnose Alzheimer’s and predict how it will progress in people with memory concerns.

  Recruiting IRCCS San Raffaele · Milan, Milano · NCT07717567

• Delirium and cognitive changes in older adults in hospital isolation

  This study tests whether older patients kept in isolation on hospital wards have more delirium or cognitive decline than similar patients not in isolation.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT07114458

• Hearing care to reduce neuropsychiatric symptoms in people with Alzheimer's and related dementias

  This trial will try a tailored, community-delivered hearing care program using HEARS devices to see if it improves communication, reduces neuropsychiatric symptoms, and eases caregiver distress in English-speaking older adults with Alzheimer's disease or related dementias who have untreated hearing loss.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06930560

• Community-based study on cognitive impairment in older adults in Hainan

  This study is looking at older adults in Hainan to see what factors affect their thinking skills and to test new tools that might help improve their brain health and physical abilities.

  Recruiting Hainan Medical College · Haikou, Hainan · NCT06686186

• Collecting data on neurodegenerative diseases progression markers

  This study is trying to find new signs that can help doctors understand how neurodegenerative diseases like Parkinson's progress, so they can improve early treatment options for patients.

  Recruiting IRCCS San Raffaele Roma · Cassino, Frosinone · NCT06596746

• Motion-based virtual cycling to improve quality of life for people with cognitive impairment

  This project will test whether motion-based virtual cycling can improve quality of life for nursing home residents with cognitive impairment.

  Recruiting Örebro University, Sweden · Örebro · NCT06466460

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.