Biomarkers That Signal Silent Strokes in High-Risk Cardiac Procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows adults undergoing transcatheter interventions with high thromboembolic risk to see if levels of neuron specific enolase (NSE) and neurofilaments (NFLs) in blood can forecast the occurrence of silent cerebral infarctions detected by imaging and subsequent cognitive decline. It does not involve an intervention beyond standard care plus biomarker measurement. Researchers will correlate biomarker data with imaging findings and long-term cognitive outcomes to identify prognostic value. The study is conducted at the Third Department of Cardiology, Aristotle University of Thessaloniki, with independent consent and monitoring requirements. Results could help stratify risk and inform post-procedure monitoring strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \> 18 years
2. Signed consent
3. Agreement on monitoring required by the study

Exclusion Criteria:

1. Age \< 18 years
2. Patients with known malignancies
3. Patients who are unable or unwilling to give consent

Where it's running

• Third Department of Cardiology, Aristotle University of Thessaloniki, Greece
  Thessaloniki, Greece Recruiting

Study contacts

• Study coordinator: Stergios Tzikas, Associate Professor of Cardiology
• Email: tzikas@auth.gr
• Phone: 002313312344

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.