Color of the defect and enamel breakdown in MIH-affected first molars
Official title: Molar-Incisor Hypomineralisation (MIH): Correlation Between Colour of Defect and Enamel Breakdown
Run by University of Basel · NCT07727200 · Data updated 2026-11-12
This study tests whether the color of the enamel defect in kids with MIH can predict enamel breakdown in their first permanent molars.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 5 Years to 8 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Basel Academic / other |
| Locations | 1 site (Basel, Canton of Basel-City) |
| Status | Recruiting |
| Started | January 9, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | March 31, 2027 |
| Registry record updated | July 27, 2026 |
| Trial ID | NCT07727200 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 5–8 years with MIH in one or more first permanent molars and fit, healthy controls of the same age.
✕Probably not a fit
Children without MIH or without enamel defects may not experience a direct benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will compare children with MIH in their first permanent molars to age-matched healthy controls to see if tooth color correlates with enamel breakdown. Standardized photography and a color reference card will be used to document defect color. The study aims to identify early indicators that could support preventive dental care and delay or avoid enamel loss. Participants are recruited from school screenings and a university dental department, with parental consent obtained.
Why it matters
Potential benefit: If a color-based link to enamel breakdown is found, clinicians could use color cues to identify teeth at higher risk and tailor preventive strategies.
How similar studies have gone: Previous work has explored MIH features; this study investigates a novel angle by correlating defect color with enamel breakdown.
Who can join: the full rules
Show full inclusion / exclusion criteria
MIH Study Group Inclusion Criteria: * Children between 5 to 8 years with MIH molars with or without hypersensitivity according to the MIH-TN Index (Bekes et al 2016) * Children with first molars in occlusion * Children fit and healthy Exclusion Criteria: * MIH first permanent molars that have already received any kind of dental treatment * Children diagnosed with HSPM (hypomineralised second primary molars) * Children older than 8 years - Children younger than 5 years * Children with any cranio-facial and/or other developmental dental defects * Children diagnosed with parafunctions (attrition/ erosion) * Children and/or parents who did not consent to the study * Children with MIH teeth that show clinically visible enamel loss during the eruption * Children without the first molars in occlusion Non- MIH Control Group Inclusion Criteria: * Children between 5 to 8 years with no clinically affected molars- Page 4 of 5 * Children fit and healthy Exclusion Criteria: * Children who have already received any kind of dental treatment on their permanent or primary teeth * Children diagnosed with MIH or any other disease of the teeth * Children older than 8 years * Children younger than 5 years * Children with any cranio-facial and/or other developmental dental defects * Children diagnosed with parafunctions (attrition/ erosion) * Children and/or parents who did not consent to the study
Where it's running
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University Centre for Dental Medicine
Basel, Canton of Basel-City, Switzerland Recruiting
Study contacts
- Study coordinator: Eirini Stratigaki, Dr.med.dent
- Email: eirini.stratigaki@unibas.ch
- Phone: +41 61 555 33 89
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Nanohydroxyapatite vs Fluoride Varnish for MIH Front Teeth
This trial tests whether a nanohydroxyapatite varnish can remineralize MIH-affected front teeth in 8–11 year-olds as effectively as a standard 5% fluoride varnish.
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Colour and sensitivity in first permanent molars with MIH
This study tests whether the colour of enamel defects in first permanent molars with MIH correlates with hypersensitivity in affected children.
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See if resin infiltration helps mild MIH in kids aged 7–11
This study tests whether resin infiltration can improve mild MIH in permanent incisors of schoolchildren aged 7 to 11 in Northern Vietnam.
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Comparing intraosseous and infiltration anesthesia for children with MIH
We will test whether intraosseous or infiltration anesthesia delivered with a computer-assisted device better reduces pain and anxiety during fillings of permanent first molars in children with MIH.
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This study is testing two types of dental sealants to see which one works better for kids with weak teeth and can help make their dental visits easier.
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Using silver diamine fluoride to improve anesthesia in children with hypomineralized molars
This study is testing if applying silver diamine fluoride before dental work can help make local anesthesia work better and reduce pain for children with sensitive molars.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.