Nanohydroxyapatite vs Fluoride Varnish for MIH Front Teeth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, 26 children with MIH-affected permanent incisors and non-cavitated lesions are assigned to nanohydroxyapatite varnish or fluoride varnish. The study uses standardized home care with non-fluoridated toothpaste and follows participants for 6 months. Remineralization is measured by ICDAS scores and DIAGNOdent readings at 1, 3, and 6 months. Outcomes focus on lesion progression or reversal and overall remineralization efficacy. The study is conducted at Tanta University with no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Child had one or more MIH-affected permanent incisors exhibiting a non-cavitated initial carious lesion on the labial surface.
* Lesions with a score of 1 or 2 according to the International Caries Detection and Assessment System (ICDAS).
* Healthy children without any systemic disease.

Exclusion Criteria:

* Severely decayed, fractured, or restored MIH-affected teeth that can't be evaluated for varnish effects.
* Presence of orthodontic appliances.
* Developmental defects of enamel other than MIH (Amelogenesis imperfecta, dentinogenesis imperfecta, erosion, dental fluorosis).
* Uncooperative patient and parent.

Where it's running

• faculty of dentistry, Tanta university
  Tanta, Egypt Recruiting

Study contacts

• Study coordinator: shaimaa eldesouky, assistant professor
• Email: shaimaaeldesouky@dent.tanta.edu.eg
• Phone: 01008994242

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Color of the defect and enamel breakdown in MIH-affected first molars

  This study tests whether the color of the enamel defect in kids with MIH can predict enamel breakdown in their first permanent molars.

  Recruiting University of Basel · Basel, Canton of Basel-City · NCT07727200

• Colour and sensitivity in first permanent molars with MIH

  This study tests whether the colour of enamel defects in first permanent molars with MIH correlates with hypersensitivity in affected children.

  Recruiting University of Basel · Basel, Canton of Basel-City · NCT07727044

• Comparing Clinpro Clear and Duraphat varnishes for dentin hypersensitivity in young adults

  This test will see if a single application of Clinpro Clear or Duraphat reduces dentin hypersensitivity in adults aged 18–40.

  Recruiting University of Concepcion, Chile · Concepción, Biobio · NCT07286344

• Titania nanoparticle–infused fluoride varnish vs conventional fluoride varnish for plaque control in fixed braces

  This will test whether a fluoride varnish that contains titania nanoparticles reduces dental plaque more than regular fluoride varnish in people aged 16–30 who are starting fixed orthodontic braces.

  Recruiting Pakistan Institute of Medical Sciences · Islamabad · NCT07180849

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.