Colour and sensitivity in first permanent molars with MIH
Official title: Molar-Incisor Hypomineralisation (MIH): Correlation Between Colour of the Defect and Hypersensitivity in Young First Permanent Molars
Run by University of Basel · NCT07727044 · Data updated 2026-11-12
This study tests whether the colour of enamel defects in first permanent molars with MIH correlates with hypersensitivity in affected children.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 5 Years to 8 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Basel Academic / other |
| Locations | 1 site (Basel, Canton of Basel-City) |
| Status | Recruiting |
| Started | January 9, 2026 |
| Main results expected | August 31, 2026 |
| Study ends | October 31, 2026 |
| Registry record updated | July 27, 2026 |
| Trial ID | NCT07727044 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 5-8 with MIH affecting one or more first permanent molars, in occlusion and otherwise healthy.
✕Probably not a fit
MIH-affected children without hypersensitivity or with non-coloured defects may not derive direct benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares children aged 5-8 with MIH-affected first permanent molars to age-matched controls with sound molars. Teeth colour is documented using standardized photography and a colour reference card, while hypersensitivity is assessed clinically. By analyzing the relationship between defect colour and reported/observed sensitivity, the study aims to see if colour cues can help predict hypersensitivity and guide preventive management. The design includes a MIH group and a healthy control group, with informed parental consent and careful exclusion criteria to minimize confounding dental conditions. No interventional treatment is described within the study protocol.
Why it matters
Potential benefit: If a strong link between colour and hypersensitivity is found, clinicians could better anticipate pain risk and tailor preventive strategies for MIH-affected teeth.
How similar studies have gone: Previous work has explored MIH characteristics, but direct correlation between enamel colour and hypersensitivity in young children remains limited and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
MIH Study Group Inclusion Criteria: * Children between 5 to 8 years with MIH molars with or without hypersensitivity according to the MIH-TN Index (Bekes et al 2016) * Children with first molars in occlusion * Children fit and healthy Exclusion Criteria: * MIH first permanent molars that have already received any kind of dental treatment * Children diagnosed with HSPM (hypomineralised second primary molars) * Children older than 8 years - Children younger than 5 years * Children with any cranio-facial and/or other developmental dental defects * Children diagnosed with parafunctions (attrition/ erosion) * Children and/or parents who did not consent to the study * Children with MIH teeth that show clinically visible enamel loss during the eruption * Children without the first molars in occlusion Non- MIH Control Group Inclusion Criteria: * Children between 5 to 8 years with no clinically affected molars * Children fit and healthy Exclusion Criteria: * Children who have already received any kind of dental treatment on their permanent or primary teeth * Children diagnosed with MIH or any other disease of the teeth * Children older than 8 years * Children younger than 5 years * Children with any cranio-facial and/or other developmental dental defects * Children diagnosed with parafunctions (attrition/ erosion) * Children and/or parents who did not consent to the study
Where it's running
-
University Centre for Dental Medicine
Basel, Canton of Basel-City, Switzerland Recruiting
Study contacts
- Principal investigator: Eirini Stratigaki, Dr.med.dent — University of Basel
- Study coordinator: Eirini Stratigaki, Dr.med.dent
- Email: eirini.stratigaki@unibas.ch
- Phone: +41 61 555 33 89
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.